B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury英文文献资料.docVIP

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B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury英文文献资料.doc

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B-Type Natriuretic Peptide in the Critically Ill with Acute Kidney Injury英文文献资料

SAGE-HindawiAccesstoResearch InternationalJournalofNephrology Volume2011,ArticleID951629,6pages doi:10.4061/2011/951629 ResearchArticle B-TypeNatriureticPeptideintheCriticallyIllwith AcuteKidneyInjury MassimodeCal,1,2MikkoHaapio,1,3DinnaN.Cruz,1PaoloLentini,1,2AndrewA.House, 1,4 1 5 IlonaBobek, 1 GraziaM.Virz`?, 1 ValentinaCorradi, 1 FlavioBasso, PasqualePiccinni, AngelaD’Angelo, 2 JamieW.Chang, 6 MitchellH.Rosner, 6 andClaudioRonco 1 1 2 3 4 5 6 DepartmentofNephrology,SanBortoloHospital,36100Vicenza,Italy DivisionofNephrology,UniversityofPadua,35122Padua,Italy DivisionofNephrology,MeilahtiHospital,HUCH,00029Helsinki,Finland DivisionofNephrology,LondonHealthSciencesCenter,LondonON,CanadaN6A5A5 IntensiveCareUnit,SanBortoloHospital,36100Vicenza,Italy DivisionofNephrology,UniversityofVirginiaHealthSystem,Charlottesville,VA22908,USA CorrespondenceshouldbeaddressedtoDinnaN.Cruz,dinnacruzmd@ Received20July2010;Revised12January2011;Accepted25April2011 AcademicEditor:AnjayRastogi Copyright?2011MassimodeCaletal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Introduction.Acutekidneyinjury(AKI)iscommonintheintensivecareunit(ICU)andassociatedwithpooroutcome.Plasma B-typenatriureticpeptide(BNP)isabiomarkerrelatedtomyocardialoverload,andiselevatedinsomeICUpatients.Thereisa highprevalenceofbothcardiacandrenaldysfunctioninICUpatients.Aims.ToinvestigatewhetherplasmaBNPlevelsinthe?rst 48hourswereassociatedwithAKIinICUpatients.Methods.Westudiedacohortof34consecutiveICUpatients.Primaryoutcome waspresenceofAKIonpresentation,orduringICUstay.Results.ForpatientswithAKIonpresentation,BNPwasstatistically higherat24and48hoursthanNo-AKIpatients(865versus148pg/mL;1380versus131pg/mL).ForpatientsdevelopingAKI during48hours,BNPwasstatisticallyhigherat0,24and48hoursthanNo-AKIpatients(510versus197pg/mL;552versus 124pg/mL;949ve