B7-H3 and Its Role in Antitumor Immunity英文文献资料.docVIP

下载本文档

3
0
约3.66万字
约 8页
2017-05-10 发布于上海
举报
版权申诉

B7-H3 and Its Role in Antitumor Immunity英文文献资料.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

B7-H3 and Its Role in Antitumor Immunity英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2010,ArticleID683875,7pages doi:10.1155/2010/683875 ReviewArticle B7-H3andItsRoleinAntitumorImmunity MartinLoos,DennisM.Hedderich,HelmutFriess,andJ¨orgKleeff ChirurgischeKlinikundPoliklinik,KlinikumRechtsderIsar,TechnischeUniversit¨atM¨unchen,IsmaningerStra?e22, 81675M¨unchen,Germany CorrespondenceshouldbeaddressedtoJ¨orgKlee?,klee?@chir.med.tu-muenchen.de Received29June2010;Revised16September2010;Accepted19October2010 AcademicEditor:C.D.Pauza Copyright?2010MartinLoosetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. B7-H3isoneofthemostrecentlyidenti?edmembersoftheB7/CD28superfamilyofcostimulatorymoleculesserving asan accessorymodulatorofT-cellresponse.Recently,B7-H3expressionhasbeenreportedinseveralhumancancersindicatingan additionalfunctionofB7-H3asaregulatorofantitumorimmunity.However,itsprecisephysiologicroleisstillelusive,because bothstimulatoryandinhibitorycapacitieshavebeendemonstrated.ThispapersummarizestheavailabledataonB7-H3inthe regulationofT-cellresponsefocusingonitspotentialroleinantitumorimmunity. 1.Introduction ligand-1), B7-DC (programmed death-1 ligand-2), PD- 1 (programmed death-1), ICOS (inducible costimulator), ICOSL(ICOS-ligand),BTLA(BandTlymphocyteattenu- ator),B7-H3,andB7-H4[3]. Tlymphocytes oftheadaptiveimmune systemareableto recognize and speci?cally respond to an incredible variety offoreignandnativeantigens.ToensureanappropriateT- cellresponse,whichisessentialtoeradicatepathogensand tomaintainself-tolerance,T-cellactivationis?nelytunedby twoindependentsignalingpathways.The?rstsignalrequires recognitionoftheantigen-bearingmajorhistocompatibility complex(MHC)onthesurfaceofantigen-presentingcells (APCs)bythecorrespondingantigen-speci?cT-cellreceptor (TCR) on T-cells. The second signal, which is antigen independent, is deliv