Are We Ready for the Use of Foxp3+ Regulatory T Cells for Immunodiagnosis and Immunotherapy in Kidney Transplantation英文文献资料.docVIP

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Are We Ready for the Use of Foxp3+ Regulatory T Cells for Immunodiagnosis and Immunotherapy in Kidney Transplantation英文文献资料.doc

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AreWeReadyfortheUseofFoxp3RegulatoryTCellsforImmunodiagnosisandImmunotherapyinKidneyTransplantation英文文献资料

HindawiPublishingCorporation JournalofTransplantation Volume2012,ArticleID397952,15pages doi:10.1155/2012/397952 ReviewArticle AreWeReadyfortheUseofFoxp3+Regulatory TCellsforImmunodiagnosisandImmunotherapyin KidneyTransplantation? FranciscoSalcido-Ochoa, 3 1 NurhashikinYusof, SusanSwee-ShanHue, 1 2 andOlafRotzschke 3 DoreenHaase, TerenceKee, 4 1 2 3 4 TregsandHLAResearchForce,DepartmentofRenalMedicine,SingaporeGeneralHospital, OutramRoad,Singapore169608 TregsandHLAResearchForce,DepartmentofPathology,SingaporeGeneralHospital, OutramRoad,Singapore169608 SingaporeImmunologyNetwork,8ABiomedicalGroveLevel04-06, ImmunosBuilding,Singapore138648 DepartmentofRenalMedicine,SingaporeGeneralHospital, OutramRoad,Singapore169608 CorrespondenceshouldbeaddressedtoFranciscoSalcido-Ochoa,francisco.salcido.ochoa@.sg Received19January2012;Accepted19March2012 AcademicEditor:DelaGolshayan Copyright?2012FranciscoSalcido-Ochoaetal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. TheexistenceofT-cellsubsetsnaturallycommittedtoperformimmunoregulationhasledtoenthusiastice?ortstoinvestigatetheir roleintheimmunopathogenesisoftransplantation.Beingabletomodulatealloresponses,regulatoryTcellscouldbeusedasan immunodiagnostictoolinclinicalkidneytransplantation.Thus,themeasurementofFoxp3transcripts,thepresenceofregulatory Tcellsinkidneybiopsies,andthephenotypiccharacterisationoftheT-cellin?ltratecouldaidinthediagnosisofrejectionandthe immunemonitoringandpredictionofoutcomesinkidneytransplantation.Interestingly,theadoptivetransferofregulatoryTcells inanimalmodelshasbeenproventodownmodulatepowerfulalloresponses,ignitingtranslationalresearchontheirpotentialuse asanimmunomodulatorytherapy.Forbusytransplantclinicians,thevastamountofinformationintheliteratureonregulatory Tcellscanbeoverwhelming.Thispaperaimstohighlightthemostapplica