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ArraySearch A Web-Based Genomic Search Engine英文文献资料
HindawiPublishingCorporation
ComparativeandFunctionalGenomics
Volume2012,ArticleID650842,10pages
doi:10.1155/2012/650842
ResearchArticle
ArraySearch:AWeb-BasedGenomicSearchEngine
TylerJ.WilsonandStevenX.Ge
DepartmentofMathematicsandStatistics,SouthDakotaStateUniversity,P.O.Box2220,Brookings,SD57007,USA
CorrespondenceshouldbeaddressedtoStevenX.Ge,xijin.ge@
Received9August2011;Revised24November2011;Accepted28November2011
AcademicEditor:IanDunham
Copyright?2012T.J.WilsonandS.X.Ge.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution
License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly
cited.
Recentadvancesinmicroarraytechnologieshaveresultedina?oodofgenomicsdata.Thislargebodyofaccumulateddatacould
beusedasaknowledgebasetohelpresearchersinterpretnewexperimentaldata.ArraySearch?ndsstatisticalcorrelationsbetween
newlyobservedgeneexpressionpro?lesandthehugesourceofwell-characterizedexpressionsignaturesdepositedinthepublic
domain.Asearchquery ofalistofgeneswill returnexperimentsonwhichthegenesaresigni?cantlyup-ordownregulated
collectively.Searchescanalsobeconductedusinggeneexpressionsignaturesfromnewexperiments.Thisresourcewillempower
biologicalresearcherswithastatisticalmethodtoexploreexpressiondatafromtheirownresearchbycomparingitwithexpression
signaturesfromalargepublicarchive.
1.Introduction
expressiondata.TheTwoGeneScatterPlottoolallowsauser
tovisualizegeneexpressionoverallmicroarrayslidesfortwo
genesasascatterplot.TheSpotHistorytoolallowsauser
toseepatternsofgeneexpressionoverallslidesforspeci?c
genes.
Genevestigator[2]providesonlinetoolstoaccesslarge
andwell-annotateddatasetsofcuratedmicroarraysamples.
The meta-pro?le analysis function of Genevestigator sum-
marizesgeneexpressiondataacrossmanysamplesaccording
tothebiologicalcontextofthesample.Eachgenesignalin
ameta-pro?le(incontrasttoanormalexpressionpro?le)
is the average of gene expression levels across samples
sharingthesamebiologicalc
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