Antioxidant Effect of Atorvastatin in Type 2 Diabetic Patients英文文献资料.docVIP

Pharmacology Pharmacy, 2010, 1, 53-59 53 doi:10.4236/pp.2010.12008 Published Online October 2010 (http://www.SciRP.org/journal/pp) Antioxidant Effect of Atorvastatin in Type 2 Diabetic Patients Najah R. Hadi , Mohammad A. Abdelhussein , Omran M. O. Alhamami , 1 2 1 1 Ammar R. Muhammad Rudha , Ekhlas Sabah 1 Department of Pharmacology, Faculty of Medicine, Kufa University, Najaf, Iraq; Department of Medicine, Faculty of Medicine, 2 Kufa University, Najaf, Iraq. Email: drnajahhadi@ Received August 26 , 2010; revised September 12 , 2010; accepted September 20 , 2010. th th th ABSTRACT Evidence has long been existed regarding the relationship between oxidative stress and diabetes. The present study was conducted to assess the effect of atorvastatin on selected oxidative stress parameters and its effect on lipid profile pa- rameters in dyslipidaemic type 2 diabetic patients. Fifty nine dyslipidaemic type 2 diabetic patients were included in this study. A full history was taken and general examination was performed. The patients were taking an oral hypogly- caemic drug (glibenclamide) during the study. The patients were followed up for 60 days and divided randomly into 2 groups. Group I (n = 31) received no drug and served as dyslipidaemic diabetic control. Group II (n = 28) received atorvastatin tablets 20 mg once daily at night. Blood samples were drawn from the patients at the beginning and after 60 days of follow up between 8:30 and 10:30 am after at least 12-14 hours fasting. Fasting blood glucose, lipid profile, selective oxidative stress parameters, glutathione S reductase (GSH), malondialdehyde (MDA) levels, glutathione S trans