Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes英文文献资料.docVIP

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Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes英文文献资料.doc

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Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2012,ArticleID135932,5pages doi:10.1155/2012/135932 ReviewArticle AreToll-LikeReceptorsandDecoyReceptorsInvolvedin theImmunopathogenesisofSystemicLupusErythematosusand Lupus-LikeSyndromes? FrancescoCiccia, GiovanniTriolo, GiulianaGuggino,1,2AnnaRitaGiardina,2 2 2 1 1 FrancescoDieli, andGuidoSireci 1 DipartimentodiBiopatologiaeBiotecnologieMedicheeForensi,Universit`adegliStudidiPalermo,DIBIMEF, CorsoTukory211,90100Palermo,Italy 2 DivisionediReumatologia,DipartimentoBiomedicodiMedicinaInternaeSpecialistica,Universit`adegliStudidiPalermo, 90133Palermo,Italy CorrespondenceshouldbeaddressedtoGuidoSireci,guido.sireci@unipa.it Received30April2011;Revised29June2011;Accepted30June2011 AcademicEditor:AnisurRahman Copyright?2012GiulianaGugginoetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Inthispaperwefocusourattentionontheroleoftwofamiliesofreceptors,Toll-likereceptors(TLR)anddecoyreceptors(DcR) involvedinthegenerationofsystemiclupuserythematosus(SLE)andlupus-likesyndromesinhumanandmousemodels.To date,thesemoleculesweredescribedinseveralautoimmunedisorderssuchasrheumatoidarthritis,antiphospholipidssyndrome, bowelin?ammation,andSLE.Here,wesummarizethe?ndingsofrecentinvestigationsonTLRandDcRandtheirroleinthe immunopathogenesisoftheSLE. 1.Introduction generationofSLEandlupus-likesyndromesinhumanand mousemodels. Systemic lupus erythematosus (SLE) and lupus-like syn- dromesaremultiorganautoimmunediseaseswhosepatho- genesisismultifactorial.Geneticandenvironmentalfactors, together with abnormalities of both the innate and the adaptive immune system, are involved. Although faulty activationofautoreactiveBlymphocytesandautoantibodies isthehallmarkofSLE,othercellsubsetsareinvolvedinthe pathogenesis of the d