Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells英文文献资料.docVIP

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Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells英文文献资料.doc

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Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells英文文献资料

HindawiPublishingCorporation JournalofOncology Volume2009,ArticleID121458,10pages doi:10.1155/2009/121458 ResearchArticle BiochaninAModulatesCellViability,Invasion,and GrowthPromotingSignalingPathwaysinHER-2-Positive BreastCancerCells VikasSehdev,JamesC.K.Lai,andAlokBhushan DepartmentofBiomedicalandPharmaceuticalSciences,CollegeofPharmacyIdaho,BiomedicalResearchInstitute, IdahoStateUniversity,Pocatello,ID83209,USA CorrespondenceshouldbeaddressedtoAlokBhushan,abhushan@ Received24June2009;Revised3November2009;Accepted10November2009 RecommendedbyBrunoVincenzi OverexpressionofHER-2receptorisassociatedwithpoorprognosisandaggressiveformsofbreastcancer.Scienti?cliterature indicatesapreventiveroleofiso?avonesincancer.SinceactivationofHER-2receptorinitiatesgrowth-promotingeventsincancer cells,westudiedthee?ectofbiochaninA(aniso?avone)onassociatedsignalingeventslikereceptoractivation,downstream signaling,andinvasivepathways.HER-2-positiveSK-BR-3breastcancercells,MCF-10Anormalbreastepithelialcells,andNIH- 3T3normal?broblastcellsweretreatedwithbiochaninA(2–100μM)for72hours.Subsequentlycellviabilityassay,western blottingandzymographywerecarried out.ThedataindicatethatbiochaninAinhibitscellviability,signalingpathways,and invasiveenzymeexpressionandactivityinSK-BR-3cancercells.BiochaninAdidnotinhibitMCF-10AandNIH-3T3cellviability. Therefore,biochaninAcouldbeauniquenaturalanticanceragentwhichcanselectivelytargetcancercellsandinhibitmultiple signalingpathwaysinHER-2-positivebreastcancercells. Copyright?2009VikasSehdevetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. 1.Introduction and (2) receptor tyrosine kinases or RTKs (like human epidermalgrowthfactorreceptorsorHERs)[7].Basedon the receptors present, tumors of the breast can be broadly classi?edinto(a)luminalAsubtype(ERand/orPR-,HER- 2-), (b) luminal B subtype (ER+ and/or PR+, sometime