Biochemical Bone Turnover Markers and Osteoporosis in Older Men Where Are We英文文献资料.docVIP

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Biochemical Bone Turnover Markers and Osteoporosis in Older Men Where Are We英文文献资料.doc

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Biochemical Bone Turnover Markers and Osteoporosis in Older Men Where Are We英文文献资料

SAGE-HindawiAccesstoResearch JournalofOsteoporosis Volume2011,ArticleID704015,5pages doi:10.4061/2011/704015 ReviewArticle BiochemicalBoneTurnoverMarkersandOsteoporosis inOlderMen:WhereAreWe? PawelSzulc INSERMUMR1033,Universit′edeLyon,H?opitalEdouardHerriot,PavillonF,Placed’Arsonval,69437Lyon,France CorrespondenceshouldbeaddressedtoPawelSzulc,pawel.szulc@inserm.fr Received29May2011;Revised8November2011;Accepted12November2011 AcademicEditor:S.Minisola Copyright?2011PawelSzulc.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,which permitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Inmenagedlessthan60,theassociationofserumandurinarylevelsofbiochemicalboneturnovermarkers(BTMs)andbone mineraldensity(BMD)isweakornotsigni?cant.Afterthisage,higherBTMlevelsarecorrelatedweakly,butsigni?cantly,with lowerBMDandfasterboneloss.LimiteddatafromthecohortstudiessuggestthatBTMmeasurementdoesnotimprovethepredic- tionoffragilityfracturesinoldermenincomparisonwithage,BMD,historyoffallsandfragilityfractures.Testosteronereplace- menttherapy(TRT)decreasesboneresorption.DuringTRT,boneformationmarkersslightlyincrease(directe?ectonosteo- blasts),thendecrease(slowdownofboneturnover).Bisphosphonates(alendronate,risedronate,ibandronate,zoledronate)induce arapiddecreaseinboneresorptionfollowedbyamilderdecreaseinboneformation.Inmenreceivingantiresorptivetherapy forprostatecancer,zoledronate,denosumabandtoremifenedecreasesigni?cantlylevelsofboneresorptionandboneformation markers.Teriparatideinducedarapidincreaseinserumconcentrationsofboneformationmarkersfollowedbyanincreasein boneresorption.WeneedmorestudiesontheutilityofBTMmeasurementfortheimprovementofthepersistenceandadherence totheanti-osteoporotictreatmentinmen. 1.Introduction 2.AssociationofBTMLevelswithBoneMineral DensityandBoneLossinMen Biochemical markers of bone turnover (BTMs) have been investigated in several male cohorts for the last 15 years. Thesestudie