Biochemical Frequency Control by Synchronisation of Coupled Repressilators An In Silico Study of Modules for Circadian Clock Systems英文文献资料.docVIP

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Biochemical Frequency Control by Synchronisation of Coupled Repressilators An In Silico Study of Modules for Circadian Clock Systems英文文献资料.doc

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Biochemical Frequency Control by Synchronisation of Coupled Repressilators An In Silico Study of Modules for Circadian Clock Systems英文文献资料

HindawiPublishingCorporation ComputationalIntelligenceandNeuroscience Volume2011,ArticleID262189,9pages doi:10.1155/2011/262189 ResearchArticle BiochemicalFrequencyControlbySynchronisationof CoupledRepressilators:AnInSilicoStudyofModulesfor CircadianClockSystems ThomasHinze,MathiasSchumann,ChristianBodenstein,InesHeiland,andStefanSchuster DepartmentofBioinformatics,FacultyofBiologyandPharmacy,FriedrichSchillerUniversityJena,E.-Abbe-Platz1-4, 07743Jena,Germany CorrespondenceshouldbeaddressedtoThomasHinze,thomas.hinze@uni-jena.de Received18March2011;Revised6July2011;Accepted6July2011 AcademicEditor:FabioBabiloni Copyright?2011ThomasHinzeetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Explorationofchronobiologicalsystemsemergesasagrowingresearch?eldwithinbioinformaticsfocusingonvariousapplications in medicine, agriculture, and material sciences. From a systems biological perspective, the question arises whether biological controlsystemsforregulationofoscillatorysignalsandtheirtechnicalcounterpartsutilisesimilarmechanisms.Ifso,modelling approachesandparameterisationadoptedfrombuildingblockscanhelptoidentifygeneralcomponentsforfrequencycontrolin circadianclocksalongwithgaininginsightintomechanismsofclocksynchronisationtoexternalstimulilikethedailyrhythmof sunlightanddarkness.Phase-lockedloopscouldbeaninterestingcandidateinthiscontext.Both,biologyandengineering,can bene?tfromauni?edviewresultingfromsystemsmodularisation.Ina?rstexperimentalstudy,weanalyseamodelofcoupled repressilators.Wedemonstrateitsabilitytosynchroniseclocksignalsinamonofrequentialmanner.Severaloscillatorsinitially deviateinphasedi?erenceandfrequencywithrespecttoexplicitreactionanddi?usionrates.Accordingly,thedurationofthe synchronisationprocessdependsondedicatedreactionanddi?usionparameterswhosesettingsstilllacktobesu?cientlycaptured analytically. 1.Introducti