Biocompatibility and Toxicity of Nanoparticles and Nanotubes英文文献资料.docVIP

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Biocompatibility and Toxicity of Nanoparticles and Nanotubes英文文献资料.doc

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Biocompatibility and Toxicity of Nanoparticles and Nanotubes英文文献资料

HindawiPublishingCorporation JournalofNanomaterials Volume2012,ArticleID548389,19pages doi:10.1155/2012/548389 ReviewArticle BiocompatibilityandToxicityofNanoparticlesandNanotubes XiaomingLi, LuWang, YuboFan, QinglingFeng, andFu-zhaiCui 1 1 1 2 2 1 KeyLaboratoryforBiomechanicsandMechanobiologyofMinistryofEducation,SchoolofBiologicalScienceandMedicalEngineering, BeihangUniversity,Beijing100191,China StateKeyLaboratoryofNewCeramicandFineProcessing,TsinghuaUniversity,Beijing100084,China 2 CorrespondenceshouldbeaddressedtoXiaomingLi,x.m.li@andYuboFan,yubofan@ Received27February2012;Accepted3April2012 AcademicEditor:ShumingZhang Copyright?2012XiaomingLietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Inrecentyears,nanoparticles(NPs)haveincreasinglyfoundpracticalapplicationsintechnology,research,andmedicine.The smallparticlesizecoupledwiththeiruniquechemicalandphysicalpropertiesisthoughttounderlinetheirexploitablebiomedical activities.Itsformmaybelatexbody,polymer,ceramicparticle,metalparticles,andthecarbonparticles.Duetotheirsmallsize andphysicalresemblancetophysiologicalmoleculessuchasproteins,NPspossessthecapacitytorevolutionisemedicalimaging, diagnostics,therapeutics,aswellascarryoutfunctionalbiologicalprocesses.Butthesefeaturesmayalsounderlinetheirtoxicity. Indeed,adetailedassessmentofthefactorsthatin?uencethebiocompatibilityandtoxicityofNPsiscrucialforthesafeand sustainabledevelopmentoftheemergingNPs.Duetotheuniquestructure,size,andshape,muche?orthasbeendedicatedto analyzingbiomedicalapplicationsofnanotubes.Thispaperfocusesonthecurrentunderstandingofthebiocompatibilityand toxicityofNPswithanemphasisonnanotubes. 1.Introduction synthesis. Its form may be latex body, polymer, ceramic particle,metalparticles,andthecarbonparticles.According to the di?erent preparation methods,