Biodegradable Blend Nanoparticles of Amphiphilic Diblock Copolymers Prepared by Nano-Precipitation Method英文文献资料.docVIP

Journal of Biomaterials and Nanobiotechnology, 2011, 2, 561-566 561 doi:10.4236/jbnb.2011.225067 Published Online December 2011 (/journal/jbnb) Biodegradable Blend Nanoparticles of Amphiphilic Diblock Copolymers Prepared by Nano-Precipitation Method Wichuda Nanthakasri, Mangkorn Srisa-Ard, Yodthong Baimark * Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahasarakham University, Mahasarakham, Thailand. * * E-mail: yodthong.b@msu.ac.th, yodthongb@ Received September 30 , 2011; revised November 15 , 2011; accepted November 26 , 2011. th th th ABSTRACT Nanoparticles of biodegradable methoxy poly(ethylene glycol)-b-polyester amphiphilic diblock copolymers have widely investigated for use as controlled release drug delivery carriers. In this work, blend nanoparticles of methoxy poly(eth- ylene glycol)-b-poly(D,L-lactide) (MPEG-b-PDLL) and methoxy poly(ethylene glycol)-b-poly(?-caprolactone) (MPEG- b-PCL) were prepared by nano-precipitation method without any surfactants. H-NMR spectra showed significant dif- 1 ference in integral peak areas, suggesting the nanoparticles with different MPEG-b-PDLL/MPEG-b-PCL blend ratios can be prepared. Transmission electron microscope revealed the blend nanoparticles had nearly spherical in shape with smooth surface. Average size of the blend nanoparticles obtained from light-scattering analysis slightly decreased with increase in blend ratio of MPEG-b-PCL. The MPEG-b-PDLL and MPEG-b-PCL were amorphous and semi-crys- talline, respectively. Thermal transition properties of the blend nanoparticles were studied with differential scanning calorimetry (DSC). The DSC results showed that glass transition temperatures of the blend nanoparticles decr