Biodegradable and bioactive porous polyurethanes scaffolds for bone tissue engineering英文文献资料.docVIP

J. Biomedical Science and Engineering, 2009, 2, 36-40 Biodegradable and bioactive porous polyurethanes scaffolds for bone tissue engineering Mei-Na Huang , Yuan-Liang Wang , Yan-Feng Luo 1 1* 1 National 985 Research Center of Bioinspired Material Science and Engineering, Bioengineering College,Chongqing University, Chongqing 400030, People’s Republic of China, Correspondence to Yuan-Liang Wang (wyl@). Tel. /fax: +86-23 Received September 22 , 2008; revised November 12 , 2008; accepted November 19 , 2008 nd th th ABSTRACT easily control of degradation rate, some researches choose diamines [10]. Guan et al [4] synthesized (poly (etherurethane urea), PEUU) with PCL and 1, 4-diiso- cyanatobutane (BDI) and putrescine. And then, PEUU was made into highly porous, biodegradable polyure- thane scaffold for tissue engineering. In this study, BDI was used, since it could release putrescine, a polyamine that is essential for cell growth and proliferation. Zhang et al [11] synthesized polyurethane by reacting of highly pure lysine diisocyanate with glucose, which resulted in major degradation products lysine and glucose (LDI- glucose), and then completely degradate and enter into human circulation system. Biodegradable porous polyurethanes scaffold have themselves opportunities in service, in- cluding controlled degradation rate, no-toxic degradation products. However, polyurethanes are lack of bioactive groups, which limits their application. This review gives the common modification methods, surface functionalization and blending modification. In finally, the review puts forward to the bulk modification as a new method to enhance the bioac