Biodegradable Polysaccharide Gels for Skin Scaffolds英文文献资料.docVIP

Journal of Biomaterials and Nanobiotechnology, 2011, 2, 216-225 doi:10.4236/jbnb.2011.23027 Published Online July 2011 (http://www.SciRP.org/journal/jbnb) Biodegradable Polysaccharide Gels for Skin Scaffolds Stephen J. Juris , Anja Mueller , Brian T. L. Smith , Samantha Johnston , Robert Walker , 1 1 1 1 1 2 Robert D. Kross 1 2 Central Michigan University, Mt. Pleasant, USA; Kross Link Labs, Bellmore, USA. Email: juris1sj@, muell1a@ Received March 2 , 2011; revised May 2 2011; accepted June 10 , 2011. nd nd th ABSTRACT A variety of skin substitutes are used in the treatment of full-thickness burns. Substitutes made from skin can harbor latent viruses, and artificial skin grafts can heal with extensive scarring, failing to regenerate structures such as glands, nerves, and hair follicles. Biodegradable and biocompatible hydrogels, however, rarely mimic the strength of the epi- dermis. Therefore, novel and practical skin scaffold materials remain to be developed. Polysaccharides form hydrogels with predicted inherent biocompatibility. This paper describes the preparation and biocompatibility of unique hydrogel skin scaffolds from plant-extracted polysaccharide mixtures of specific sources, types, and molecular weight fractions. These hydrogels have a range of mechanical and degradation properties with the potential to fulfill the multiple, di- verse functions of artificial skin, including protection, compatibility with different cell types, biodegradation, and re- lease of needed signals for cell growth and wound healing. Keywords: Hydrogel, Polysaccharides, Skin Scaffold 1. Introduction limited biocompatible and biodegradable materials a