Bupropion and Citalopram in the APP23 Mouse Model of Alzheimers Disease A Study in a Dry-Land Maze英文文献资料.docVIP

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Bupropion and Citalopram in the APP23 Mouse Model of Alzheimers Disease A Study in a Dry-Land Maze英文文献资料.doc

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Bupropion and Citalopram in the APP23 Mouse Model of Alzheimers Disease A Study in a Dry-Land Maze英文文献资料

HindawiPublishingCorporation InternationalJournalofAlzheimer’sDisease Volume2012,ArticleID673584,7pages doi:10.1155/2012/673584 ResearchArticle BupropionandCitalopramintheAPP23MouseModelof Alzheimer’sDisease:AStudyinaDry-LandMaze KatharinaL.Neumeister 1andMatthiasW.Riepe 1,2 1 2 DivisionofMentalHealthOldAgePsychiatry,PsychiatryII,UlmUniversity,89312G¨unzburg,Germany DepartmentofGeriatricsOldAgePsychiatry,PsychiatryII,UlmUniversity,Ludwig-Heilmeyer-Stra?e2, 89312G¨unzburg,Germany CorrespondenceshouldbeaddressedtoMatthiasW.Riepe,matthias.riepe@uni-ulm.de Received29March2012;Accepted3September2012 AcademicEditor:FrancescoPanza Copyright?2012K.L.NeumeisterandM.W.Riepe. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Background.IncipientAlzheimer’sdiseaseisoftendisguisedasdepressivedisorder.OverthecourseofAD,depressivesymptoms areevenmorefrequent.Hence,treatmentwithantidepressantsiscommoninAD.Itwasthegoalofthepresentstudytoassess whethertwocommonantidepressantswithdi?erentmechanismsofactiona?ectspatiallearninginatransgenicanimalmodelof Alzheimer’sdisease.Methods.Weassessedspatialmemoryofmalewild-typeandB6C3-Tg(APPswe,PSEN1dE9)85Dbo(APP23) transgenicanimalsinacomplexdry-landmaze.Animalsweretreatedwithcitalopram(10mg/kg)andbupropion(20mg/kg). Results.Movingandrestingtimeuntil?ndingthegoalzonedecreasedin4.5-month-oldsham-treatedwild-type animalsand, toalesserextent,inAPP23animals.Comparedwithsham-treatedAPP23animals,treatmentwithbupropionreducedresting timeandincreasedspeed.Ontreatmentwithcitalopram,movingandrestingtimewereunchangedbutspeeddecreased.Length ofthepathtothegoalzonedidnotchangeoneitherbupropionorcitalopram.Conclusion.Bupropionincreasespsychomotor activityinAPP23transgenicanimals,whilecitalopramslightlyreducespsychomotoractivity.Spatiallearningperseisuna?ected bytreatmentwitheitherbupropionorcitalopram.