Cardiac Response to Chronic Intermittent Hypoxia with a Transition from Adaptation to Maladaptation The Role of Hydrogen Peroxide英文文献资料.docVIP

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Cardiac Response to Chronic Intermittent Hypoxia with a Transition from Adaptation to Maladaptation The Role of Hydrogen Peroxide英文文献资料.doc

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Cardiac Response to Chronic Intermittent Hypoxia with a Transition from Adaptation to Maladaptation The Role of Hydrogen Peroxide英文文献资料

HindawiPublishingCorporation OxidativeMedicineandCellularLongevity Volume2012,ArticleID569520,12pages doi:10.1155/2012/569520 ReviewArticle CardiacResponsetoChronicIntermittent HypoxiawithaTransitionfromAdaptationtoMaladaptation: TheRoleofHydrogenPeroxide QuanLiu, JunCai, andLuCai XiaYin,1,2YangZheng,1 1 2 2 1 2 TheCardiovascularCenter,TheFirstHospitalofJilinUniversity,Changchun130021,China DepartmentofPediatrics,KosairChildrenHospitalResearchInstitute,UniversityofLouisville,Louisville,KY40202,USA CorrespondenceshouldbeaddressedtoYangZheng,zhengyanghappy07@andLuCai,l0cai001@ Received7February2012;Accepted20March2012 AcademicEditor:IvanSpasojevic Copyright?2012XiaYinetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,which permitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Obstructivesleepapnea(OSA)isahighlyprevalentrespiratorydisorderofsleep,andassociatedwithchronicintermittenthypoxia (CIH).ExperimentalevidenceindicatesthatCIHisauniquephysiologicalstatewithpotentially“adaptive”and“maladaptive” consequences for cardio-respiratory homeostasis. CIH is also a critical element accounting for most of cardiovascular complications of OSA. Cardiac response to CIH is time-dependent, showing a transition from cardiac compensative (such as hypertrophy) to decompensating changes (such as failure). CIH-provoked mild and transient oxidative stress can induce adaptation,butsevereandpersistentoxidativestressmayprovokemaladaptation.Hydrogenperoxideasoneofmajorreactive oxygen species plays an important role in the transition of adaptive to maladaptive response to OSA-associated CIH. This mayaccountforthefactthatalthoughoxidativestresshasbeenrecognizedasadriverofcardiacdiseaseprogression,clinical interventionswithantioxidantshavehadlittleornoimpactonheartdiseaseandprogression.Herewefocusontheroleofhydrogen peroxideinCIHandOSA,tryingtooutlinethepotentialofantioxidativether