Carnosine and N-Acetylcarnosine Induce Inhibition of UVB Erythema in Human Skin英文文献资料.docVIP

Journal of Cosmetics, Dermatological Sciences and Applications, 2011, 1, 177-179 177 doi:10.4236/jcdsa.2011.14027 Published Online December 2011 (http://www.SciRP.org/journal/jcdsa) Carnosine and N-Acetylcarnosine Induce Inhibition of UVB Erythema in Human Skin Massimiliano Nino , Barbara Iovine, Pietro Santoianni * Department of Systematic Pathology, Section of Dermatology University Federico II of Naples, Naples, Italy. * E-mail: massimilianonino@yahoo.it Received June 17 , 2011; revised August 5 , 2011; accepted August 27 , 2011. th th th ABSTRACT Background: Carnosine is a low molecular weight water soluble biological dipeptide, composed of alanine and his- tidine, present in a levorotatory form in mammalian tissues. Interesting activities are related to the detoxification from free radical species and byproducts of membrane lipids peroxidation. Objectives: The aim of the present study was to evaluate the photoprotective properties of carnosine and acetylated carnosine when applied to human skin. Materials and methods: Carnosine and N-acetylcarnosine at 0.5% solution in water were applied before and after UVB irradia- tion in twenty healthy volunteers with phototype 2 or 3. 9 patients were males and 11 females, 25 to 46 years of age. None of the patients had a positive case history for photodermatoses or had received any sun exposure. The minimal erythemal dose (MED) for UVB was determined before the study with a UVB Philips TL12 lamp with a radiance of 4 mW/cm 2 and a 290 - 320 nm emission spectrum. Results: Carnosine solution obtained 3.6% reduction of erythema (compared to MED) and N-acetylcarnosine 7.3% reduction. Conclusions: An antioxidant capacity of N-acetylcarnosine and carnosine was shown, probably more significant with vehicles improving skin penetration of the substances