Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing英文文献资料.docVIP

HindawiPublishingCorporation DermatologyResearchandPractice Volume2010,ArticleID790234,11pages doi:10.1155/2010/790234 ReviewArticle CellularandMolecularCharacteristicsofScarlessversusFibrotic WoundHealing LathaSatish 1andSandeepKathju 1,2 1 CenterforGenomicSciences,Allegheny-SingerResearchInstitute,AlleghenyGeneralHospital,320EastNorthAvenue, Pittsburgh,PA15212,USA 2 DepartmentofMicrobiologyandImmunology,DrexelUniversityCollegeofMedicine,AlleghenyCampus, Pittsburgh,PA15212,USA CorrespondenceshouldbeaddressedtoLathaSatish,lsatish@ Received27March2010;Accepted24November2010 AcademicEditor:HayesB.Gladstone Copyright?2010L.SatishandS.Kathju. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. The purpose of this paper is to compare and contrast the discrete biology di?erentiating fetal wound repair from its adult counterpart.Integumentarywoundhealinginmammalianfetusesisessentiallydi?erentfromwoundhealinginadultskin.Adult (postnatal)skinwoundhealingisacomplexandwell-orchestratedprocessspurredbyattendantin?ammationthatleadstowound closurewithscarformation.Incontrast,fetalwoundrepairoccurswithminimalin?ammation,fasterre-epithelialization,and withouttheaccumulationofscar.Althoughresearchintoscarlesshealingbegandecadesago,thecriticalmolecularmechanisms driving the process of regenerative fetal healing remain uncertain. Understanding the molecular and cellular events during regenerativehealingmayprovidecluesthatonedayenableustomodulateadultwoundhealingandconsequentlyreducescarring. 1.Introduction can cause substantial hearing loss, and constriction of the nasal apertures can interfere with respiration, smell, and derivatively, taste. Scar contractures following burn injury arewellknowntoprogresstomicrostomia,nasalstenosis, lip or eyelid ectropion if severe enough. They can lead to restriction of neck movement and permanent mou