Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimers Disease Clinical and Neurochemical Correlates英文文献资料.docVIP

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Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimers Disease Clinical and Neurochemical Correlates英文文献资料.doc

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Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimers Disease Clinical and Neurochemical Correlates英文文献资料

SAGE-HindawiAccesstoResearch InternationalJournalofAlzheimer’sDisease Volume2011,ArticleID495025,6pages doi:10.4061/2011/495025 ClinicalStudy CerebrospinalFluidLevelsofsAPPαandsAPPβinLewyBodyand Alzheimer’sDisease:ClinicalandNeurochemicalCorrelates Ezra Mulugeta,1,2 Elisabet Londos, 3 Oskar Hansson, CliveBallard, Ragnhild Skogseth, 3 2 1 LennartMinthon, 3 KajBlennow, 4 HenrikZetterberg, 4andDagAarsland1,5,6 1 2 3 4 CentreforAge-RelatedMedicine,StavangerUniversityHospital,4068Stavanger,Norway WolfsonCentreforAge-RelatedDiseases,King’sCollegeLondon,LondonSE11UL,UK ResearchUnit,DepartmentofClinicalSciences,Malm¨o,UniversityofLund,Lund,Norway DepartmentofPsychiatryandNeurochemistry,InstituteofNeuroscienceandPhysiology,TheSahlgrenskaAcademy, UniversityofGothenburg,Molndal,Gothenburg,Sweden 5 6 NVSDepartment,KIAlzheimerDiseaseResearchCenter,KarolinskaInstitutet,Novum,14186Stockholm,Sweden InstituteofClinicalMedicine,AkershusUniversityHospital,UniversityofOslo,Oslo,Norway CorrespondenceshouldbeaddressedtoDagAarsland,daarsland@ Received7April2011;Revised13June2011;Accepted19July2011 AcademicEditor:LucillaParnetti Copyright?2011EzraMulugetaetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Wemeasuredcerebrospinal?uid(CSF)levelsofthesolubleisoformsofamyloidprecursorprotein(APP;sAPPαsAPPβ)andother CSFbiomarkersin107patientswithAlzheimer’sdisease(AD),dementiawithLewybodydementia(DLB),Parkinson’sdisease dementia(PDD),andnormalcontrols(NC)usingcommercialkits.DLBandPDDwerecombinedinaLewybodydementia group(LBD).Nodi?erenceswereobservedinsAPPαandsAPPβlevelsbetweenthegroups.Signi?cantcorrelationswereobserved betweensAPPαandsAPPβandbetweensAPPβandMini-MentalStateExaminationscoresinthetotalgroupanalysisaswellas whenLBDandADgroupswereanalyzedseparately.sAPPαandsAPPβlevelscorrelatedwithAβ38,Aβ40,Aβ42,andTauinthe