Carbon-Nanofibers-Based Micro-Nanodevices for Neural-Electrical and Neural-Chemical Interfaces英文文献资料.docVIP

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Carbon-Nanofibers-Based Micro-Nanodevices for Neural-Electrical and Neural-Chemical Interfaces英文文献资料.doc

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Carbon-Nanofibers-Based Micro-Nanodevices for Neural-Electrical and Neural-Chemical Interfaces英文文献资料

HindawiPublishingCorporation JournalofNanomaterials Volume2012,ArticleID280902,6pages doi:10.1155/2012/280902 ReviewArticle Carbon-Nano?bers-BasedMicro-/Nanodevicesfor Neural-ElectricalandNeural-ChemicalInterfaces HongzhiZhang, MeiYu, LeiXie, LinlinJin, 1 1 1 1andZheYu1,2,3 1 BiomedicalMicrodevicesResearchLaboratory,ShenzhenInstitutesofAdvancedTechnology,ChineseAcademyofSciences, ShenzhenUniversityTown,Shenzhen518055,China 2 3 KeyLaboratoryforHealthInformatics,ChineseAcademyofSciences,Shenzhen518055,China ShenzhenKeyLaboratoryofNeuropsychiatricModulation,Shenzhen518055,China CorrespondenceshouldbeaddressedtoZheYu,zhe.yu@ Received16December2011;Revised24February2012;Accepted24February2012 AcademicEditor:TongLin Copyright?2012HongzhiZhangetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Carbonnano?bers(CNFs)haveshowngreatpotentialsfordevelopmentofmicro-/nanodevicesforneuralinterfacesduetotheir suitable properties, such as chemical stability, good electrical conductivity, ultramicro size with low electrical impedance, 3D structureswithhighsurface-to-volumeratio,andlong-termbiocompatibility.Inthispaper,wereviewtheapplicationsofCNFs asneural-electricalinterfacesandneural-chemicalinterfacesforneuralrecordingandstimulation,electroconductivenano?brous sca?oldsfornervetissueengineering,drugandgenedelivery,andneurochemicalsensing.TheCNFs-basedmicro-/nanodevices providenewplatformsto?ne-tuneelectricalandchemicalcuesofneuronsatsubcellularnanoscale,whichcanbeusedforboth fundamentalstudiesofmaterial-cellinteractionsandthedevelopmentofchronicallystable,implantableneuralinterfacedevices. Furtherdevelopmentofthistechnologymaypotentiallyenableahighlymultiplexclosed-loopsystemwithmultifunctionsfor neuromodulationandneuroprostheses. 1.Introduction patientswithdiseasesordisabilitiesofneuralfunction[11, 12