Carbon Dioxide Insufflation in Routine Colonoscopy Is Safe and More Comfortable Results of a Randomized Controlled Double-Blinded Trial英文文献资料.docVIP

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Carbon Dioxide Insufflation in Routine Colonoscopy Is Safe and More Comfortable Results of a Randomized Controlled Double-Blinded Trial英文文献资料.doc

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Carbon Dioxide Insufflation in Routine Colonoscopy Is Safe and More Comfortable Results of a Randomized Controlled Double-Blinded Trial英文文献资料

HindawiPublishingCorporation DiagnosticandTherapeuticEndoscopy Volume2011,ArticleID378906,6pages doi:10.1155/2011/378906 ClinicalStudy CarbonDioxideInsuf?ationinRoutineColonoscopyIs SafeandMoreComfortable:ResultsofaRandomizedControlled Double-BlindedTrial M.Geyer, U.Guller, andC.Beglinger 1 2 3 1 2 3 GastroenterologieWettingen,5430wettingen,Switzerland DivisionofVisceralSurgeryandTransplantation,DepartmentofSurgery,UniversityofBern,3010Bern,Switzerland DepartmentofGastroenterologyandHepatology,UniversityHospitalBasel,4031Basel,Switzerland CorrespondenceshouldbeaddressedtoM.Geyer,geyer@gastroenterologie-wettingen.ch Received13January2011;Accepted8April2011 AcademicEditor:Jean-MarcDumonceau Copyright?2011M.Geyeretal. This isanopen access article distributed under the Creative CommonsAttribution License, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Manypatientsexperiencepainanddiscomfortaftercolonoscopy.Carbondioxide(CO2)canreduceperiproceduralpainalthough airinsu?ationremainedthestandardprocedure.Theobjectiveofthisdouble-blinded,randomizedcontrolledtrialwastoevaluate whetherCO2 insu?ationdoesdecrease painandbloatingduringandaftercolonoscopycomparedtoroomair.Methods .219 consecutivepatientsundergoingcolonoscopywererandomizedtoeitherCO2orairinsu?ation.Propofolwasusedinallpatients forsedation.TranscutaneousCO2wascontinuouslymeasuredwithacapnographasasafetyparameter.Pain,bloating,andoverall satisfactionwere assessedatregular intervalsbefore andafter theprocedure. Results (dataare mean ±SD).110patients were randomizedtoCO and109toroomair.Thebaselinecharacteristicsweresimilarinbothgroups.Themeanpropofoldosewas 2 notdi?erentbetweenthetreatments,aswerethetimetoreachtheileumandthewithdrawaltime.pCO2attheendoftheprocedure was35.2± 4.3mmHg(CO2group)versus35.6± 6.0mmHgintheroomairgroup(P.05).Norelevantcomplicationoccurred ineithergroup.Therewassigni?cantlylessbloatingfortheCO g