Breast Cancer in the Setting of HIV英文文献资料.docVIP

SAGE-HindawiAccesstoResearch PathologyResearchInternational Volume2011,ArticleID925712,4pages doi:10.4061/2011/925712 CaseReport BreastCancerintheSettingofHIV MitulPalan, SamiShousha, Jonathankrell, andJustinStebbing 1 2 1 1 1 DepartmentofMedicalOncology,TheHammersmithHospitalsNHSTrust, andCharingCrossHospital,ImperialCollegeHealthcareNHSTrust,FulhamPalaceRoad,LondonW68RF,UK DepartmentofHistopathology,andCharingCrossHospital,ImperialCollegeHealthcareNHSTrust, FulhamPalaceRoad,LondonW68RF,UK 2 CorrespondenceshouldbeaddressedtoMitulPalan,mitul.palan06@imperial.ac.ukand JustinStebbing,j.stebbing@imperial.ac.uk Received29November2010;Revised5April2011;Accepted5April2011 AcademicEditor:LironPantanowitz Copyright?2011MitulPalanetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Oncogenesisinimmunocompromisedpatientsoccursduetoanumberoffactorsincludingreducedimmunesurveillanceorother viralpathogens.Breastcancer,unlikeothernon-AIDS-de?ningcancers,doesnotappearassociatedandhasrarelybeenreported. Wedescribeacasewithevidenceofimmunereactivityaroundthetumor,butnotinthetumoritself. 1.Introduction 2.CaseVignette VeryfewcasesofbreastcancerinHIV-infectedwomenare recorded in the literature; approximately 46 HIV-infected women to this date have been recorded. According to theWorldHealthOrganization,approximately33.4million people(adultsandchildren) intheworldwere living with HIVin2008,themajorityofwhichresidedinsub-Saharan Africa[1].Averywiderangeofcancershavebeenassociated withanincreasedincidenceinpeoplelivingwithHIV[2,3]. AswellasneoplasmssuchasKaposi’ssarcoma[4]andNon- Hodgkin’slymphoma[5],afocusofrecentresearchhasbeen thenon-AIDS-de?ning cancers, that is, tumorsotherthan Kaposi sarcoma, non-Hodgkin lymphoma, and cancer of the uterine cervix, in the setting of HIV. However, of the non-A