Carbon Nanotubes in Cancer Therapy and Drug Delivery英文文献资料.docVIP

Carbon Nanotubes in Cancer Therapy and Drug Delivery英文文献资料.doc

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Carbon Nanotubes in Cancer Therapy and Drug Delivery英文文献资料

HindawiPublishingCorporation JournalofDrugDelivery Volume2012,ArticleID837327,10pages doi:10.1155/2012/837327 ReviewArticle CarbonNanotubesinCancerTherapyandDrugDelivery AbdelbaryM.A.Elhissi, WaqarAhmed, IsrarUlHassan, 1 2 3 Vinod.R.Dhanak, andAntonyD’Emanuele 1 4 1 InstituteofNanotechnologyandBioengineering,SchoolofPharmacyandBiomedicalSciences,UniversityofCentralLancashire, PrestonPR12HE,UK 2 InstituteofNanotechnologyandBioengineering,SchoolofComputing,EngineeringandPhysicalSciences, UniversityofCentralLancashire,PrestonPR12HE,UK 3 4 MathematicsandSciencesUnit,CollegeofArtandAppliedSciences,DhofarUniversity,P.O.Box2509,211Salalah,Oman DepartmentofPhysics,UniversityofLiverpool,LiverpoolL693BX,UK CorrespondenceshouldbeaddressedtoAbdelbaryM.A.Elhissi,aelhissi@uclan.ac.uk Received13June2011;Accepted9August2011 AcademicEditor:RassoulDinarvand Copyright?2012AbdelbaryM.A.Elhissietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Carbonnanotubes(CNTs)havebeenintroducedrecentlyasanovelcarriersystemforbothsmallandlargetherapeuticmolecules. CNTscanbefunctionalized(i.e.,surfaceengineered)withcertainfunctionalgroupsinordertomanipulatetheirphysicalorbio- logicalproperties.InadditiontotheabilityofCNTstoactascarriersforawiderangeoftherapeuticmolecules,theirlargesurface areaandpossibilitytomanipulatetheirsurfacesandphysicaldimensionshavebeenexploitedforuseinthephotothermaldestruc- tionofcancercells.ThispaperpaperwilldiscussthetherapeuticapplicationsofCNTswithamajorfocusontheirapplicationsfor thetreatmentofcancer. 1.Introduction to functionalize these molecules with organic groups and renderthemsolublethatopenedthewaytobioapplications ofCNTs.Duetotheirhighsurfacearea,theyarecapableof adsorbingorconjugatingwithawidevarietyoftherapeutic molecules. Thus, CNTs can be surface engineered (i.e., functionalized) in

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