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Carbon Nanotubes in Cancer Therapy and Drug Delivery英文文献资料
HindawiPublishingCorporation
JournalofDrugDelivery
Volume2012,ArticleID837327,10pages
doi:10.1155/2012/837327
ReviewArticle
CarbonNanotubesinCancerTherapyandDrugDelivery
AbdelbaryM.A.Elhissi, WaqarAhmed, IsrarUlHassan,
1 2 3
Vinod.R.Dhanak, andAntonyD’Emanuele
1
4
1
InstituteofNanotechnologyandBioengineering,SchoolofPharmacyandBiomedicalSciences,UniversityofCentralLancashire,
PrestonPR12HE,UK
2
InstituteofNanotechnologyandBioengineering,SchoolofComputing,EngineeringandPhysicalSciences,
UniversityofCentralLancashire,PrestonPR12HE,UK
3
4
MathematicsandSciencesUnit,CollegeofArtandAppliedSciences,DhofarUniversity,P.O.Box2509,211Salalah,Oman
DepartmentofPhysics,UniversityofLiverpool,LiverpoolL693BX,UK
CorrespondenceshouldbeaddressedtoAbdelbaryM.A.Elhissi,aelhissi@uclan.ac.uk
Received13June2011;Accepted9August2011
AcademicEditor:RassoulDinarvand
Copyright?2012AbdelbaryM.A.Elhissietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution
License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly
cited.
Carbonnanotubes(CNTs)havebeenintroducedrecentlyasanovelcarriersystemforbothsmallandlargetherapeuticmolecules.
CNTscanbefunctionalized(i.e.,surfaceengineered)withcertainfunctionalgroupsinordertomanipulatetheirphysicalorbio-
logicalproperties.InadditiontotheabilityofCNTstoactascarriersforawiderangeoftherapeuticmolecules,theirlargesurface
areaandpossibilitytomanipulatetheirsurfacesandphysicaldimensionshavebeenexploitedforuseinthephotothermaldestruc-
tionofcancercells.ThispaperpaperwilldiscussthetherapeuticapplicationsofCNTswithamajorfocusontheirapplicationsfor
thetreatmentofcancer.
1.Introduction
to functionalize these molecules with organic groups and
renderthemsolublethatopenedthewaytobioapplications
ofCNTs.Duetotheirhighsurfacearea,theyarecapableof
adsorbingorconjugatingwithawidevarietyoftherapeutic
molecules. Thus, CNTs can be surface engineered (i.e.,
functionalized) in
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