Breast Carcinoma Cells in Primary Tumors and Effusions Have Different Gene Array Profiles英文文献资料.docVIP

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Breast Carcinoma Cells in Primary Tumors and Effusions Have Different Gene Array Profiles英文文献资料.doc

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Breast Carcinoma Cells in Primary Tumors and Effusions Have Different Gene Array Profiles英文文献资料

HindawiPublishingCorporation JournalofOncology Volume2010,ArticleID969084,14pages doi:10.1155/2010/969084 ResearchArticle BreastCarcinomaCellsinPrimaryTumorsandEffusionsHave DifferentGeneArrayPro?les SophyaKonstantinovsky, YoavSmith, So?aZilber, HeleneTuftStavnes, 1 2 3 4 Anne-MarieBecker, 4 JahnM.Nesland,4,5ReuvenReich,1,6andBenDavidson 4,5 1 DepartmentofPharmacologyandExperimentalTherapeutics,SchoolofPharmacy,FacultyofMedicine, TheHebrewUniversityofJerusalem,Jerusalem91120,Israel 2 3 4 5 6 GenomicDataAnalysisUnit,TheHebrewUniversityofJerusalem,Jerusalem91120,Israel DepartmentofPathology,RabinMedicalCenter,PetachTikva49100,Israel DivisionofPathology,TheNorwegianRadiumHospital,OsloUniversityHospital,0310Oslo,Norway FacultyDivisionNorwegianRadiumHospital,TheMedicalFaculty,UniversityofOslo,0316Oslo,Norway DavidR.BloomCenterforPharmacy,TheHebrewUniversityofJerusalem,Israel CorrespondenceshouldbeaddressedtoReuvenReich,reich@cc.huji.ac.il Received22April2009;Accepted2June2009 AcademicEditor:Tian-LiWang Copyright?2010SophyaKonstantinovskyetal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Thedetectionofbreastcarcinomacellsine?usionsisassociatedwithrapidlyfataloutcome,butthesecellsarepoorlycharacterized at the molecular level. This study compared the gene array signatures of breast carcinoma cells in primary carcinomas and e?usions.Thegeneticsignatureof10primary tumorsand10e?usionswasanalyzedusingtheArray-ReadyOligosetforthe HumanGenomeplatform.ResultsforselectedgeneswerevalidatedusingPCR,Westernblotting,andimmunohistochemistry. Array analysis identi?ed 255 signi?cantly downregulated and 96 upregulated genes in the e?usion samples. The majority of di?erentially expressed genes were part of pathways involved in focal adhesion, extracellular matrix-cell interaction, and the