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Breast Cancer Biology The Multifaceted Roles of Mesenchymal Stem Cells英文文献资料.doc

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Breast Cancer Biology The Multifaceted Roles of Mesenchymal Stem Cells英文文献资料

HindawiPublishingCorporation JournalofOncology Volume2008,ArticleID425895,7pages doi:10.1155/2008/425895 ReviewArticle BreastCancerBiology:TheMultifacetedRolesof MesenchymalStemCells ShyamA.Patel,1,2AndrewC.Heinrich, 2 BobbyY.Reddy, BalajiSrinivas, 2 2 2 NicoleHeidaran, 2 andPranelaRameshwar 1 2 GraduateSchoolofBiomedicalSciences,UniversityofMedicineandDentistryofNewJersey,Newark,NJ07103,USA DivisionofHematologyandOncology,DepartmentofMedicine,NewJerseyMedicalSchool,UniversityofMedicineand DentistryofNewJersey,Newark,NJ07103,USA CorrespondenceshouldbeaddressedtoPranelaRameshwar,rameshwa@ Received23July2008;Accepted8October2008 RecommendedbyMassimoAglietta Recentupsurgeintheinterestofbreastcancermetastasisispartlyattributedtothediscoveryofnovel,yetunclear,mechanismsof breastcancerinteractionwithsitesofdistantmetastasissuchasthebonemarrowmicroenvironment.Inthisreview,wediscussthe signi?canceoftheinteractionsbetweenbreastcancercellsandcellsofthebonemarrow.Thisisasubjectofintenseresearchstudies aimtoprovidenewmethodsoftreatmentsandperhapstheidenti?cationofnewdrugtargets.Thisreviewalsodiscussestherole ofin?ammationandthebimodalfunctionofthetransforminggrowthfactor-βsignalingpathwayintheprocessoftumorigenesis. Webringattentiontofutureprospectsinbreastcancerresearch,includingtheroleofmicroRNAsincancerquiescenceinthe bonemarrowandtheapplicationofmicroRNAstobasicsciencediscoveriesinoncology.Finally,wediscussthecancerstemcell hypothesis,whichisnotanewidea,buthasresurgedwithinvestigativequestions. Copyright?2008ShyamA.Pateletal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. 1.Introduction hypercalcemia[5].Fractures,compressionofthespinalcord, and reduced quality of life are the ultimate outcomes of bone metastasis [5]. Recent improvements in chemother- apy for advanced breast cancer treatment, although to be credited,have