Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor B Is a Steady Feature of Urinary Bladder Carcinogenesis英文文献资料.docVIP

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Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor B Is a Steady Feature of Urinary Bladder Carcinogenesis英文文献资料.doc

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Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor B Is a Steady Feature of Urinary Bladder Carcinogenesis英文文献资料

HindawiPublishingCorporation AdvancesinUrology Volume2010,ArticleID871356,8pages doi:10.1155/2010/871356 ResearchArticle CoordinatedIncreasedExpressionof Cyclooxygenase2andNuclearFactorκBIsaSteadyFeatureof UrinaryBladderCarcinogenesis StylianosKontos,1,2GeorgiaSotiropoulou-Bonikou, 3 AthinaKominea, 1 4 MariaMelachrinou, 1 EleniBalampani, 5 andDionysisBonikos 1 2 3 4 5 DepartmentofPathology,MedicalSchool,UniversityofPatras,26504Rion,Greece DepartmentofUrology,GeneralHospitalofNikaia,18543Peiraeus,Greece DepartmentofAnatomyandHistology-Embryology,MedicalSchool,UniversityofPatras,26504Rion,Greece DepartmentofPathology,AegionGeneralHospital,25100Aegion,Greece DepartmentofMicrobiology,GeneralHospitalofNikaia,18543Peiraeus,Greece CorrespondenceshouldbeaddressedtoStylianosKontos,kontostylianos@ Received7June2010;Accepted15July2010 AcademicEditor:DouglasS.Scherr Copyright?2010StylianosKontosetal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Objectives.Theinescapablerelationshipbetweenchronicin?ammationandcarcinogenesishaslongbeenestablished.Ourobjective was to investigate COX-2 and NF-κB immunohistochemical expression in a large series of normal epithelium and bladder carcinomas.Methods.Immunohistochemicalmethodologywasperformedonformalin-?xed,para?n-embeddedsectionsfrom urinary bladder carcinomas of 140 patients (94 males and 46 females with bladder carcinomas). Results. COX-2 expression is increased in the cytoplasm of bladder cells, during loss of cell di?erentiation (rs = 0.61, P-value .001) and in muscle invasivecarcinomas(P-value .001).AstrongpositiveassociationbetweentumorgradeandnuclearexpressionofNFκ Bhas beenestablished.ApositivecorrelationbetweenCOX-2andnuclearNFκBimmunoreactivitywasobserved. Conclusions .The possiblecoordinatedupregulationofNFκBandCOX-2,duringbladdercarcinogenesis,indicatesthatage