光学分子影像学及其应用.pdfVIP

# 2024 # 中国医学影像技术2008 年第24 卷第 12 期 Chin J Med Imaging Technol, 2008, Vol 24,No 12 ¯ Optical molecular imagin g an d its applicat ion SH I Li2xing 1, 2 , ZHANG J i2wu 1,2* ( 1. School of Lif e Science and Technolog y, Shanghai J iao Tong Univer ity , Shang hai 200240, China ; 2. Car e tr eam H ealth Global RD Center , Shanghai 201206, China) [Ab stract ] Optical molecular imaging is a rapidly developing biomedical imaging technology that enables the examination of cellular and molecular processes in vivo by bioluminescence or fluorescent proteins or fluorescent dyes1 It has some advanta2 ges compared with M and radionuclide imaging, etc, such as noninvasiveness, high sensitivity, low cost and strong pene2 tration of near infrared (NI ) fluorochrome1 Optical contrast agent has been developing very fast, especially on nanoparti2 cle, nanoshells and quantum dots1 Probes labeled with near infrared emitting fluorochromes have the additional potential to translate to human clinical use1 In this review, the current modalities of optical molecular imaging and its applications in biol2 ogy, medicine and pharmacy were presented1 [K ey wor ds] Optical molecular imaging; Biology; Medicine; Pharmacy 1,2 1,2* , (1.上海交通大学生命科学技术学院, 上海 200240;2.Carestream Health 全球研发中心,上海 201206) [ ] 光学分子影像学是一种快速发展的生 医学影像技术, 它可以利用生 自发光或荧光蛋白或荧光染料,在分子 和细胞层面上对在体的特定生 过程进行定性和定量研究。光学分子影像学同磁共振、核素成像等技术相比, 具有无创 性、高敏感性、成像价格低、近红外荧光穿透力强等优点。光学对比剂,特别纳米颗粒