A at Single Nucleotide Polymorphism-358 Is Required for G at -420 to Confer the Highest Plasma Resistin in the General Japanese Population 英文参考文献.docVIP

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A at Single Nucleotide Polymorphism-358 Is Required for G at -420 to Confer the Highest Plasma Resistin in the General Japanese Population 英文参考文献.doc

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A at Single Nucleotide Polymorphism-358 Is Required for G at -420 to Confer the Highest Plasma Resistin in the General Japanese Population 英文参考文献

AatSingleNucleotidePolymorphism-358IsRequiredfor Gat-420toConfertheHighestPlasmaResistininthe GeneralJapanesePopulation HiroshiOnuma1,2.,YasuharuTabara2,3.,RyoichiKawamura1.,TakashiTanaka4,JunOhashi5 ,Wataru Nishida1,YasunoriTakata1,MasaakiOchi1,KazuyaYamada6,RyuichiKawamoto7,KatsuhikoKohara2,8, TetsuroMiki2,8,HideichiMakino1¤,HaruhikoOsawa1,2* 1Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan, 2Ehime Proteo-Medicine Research Center, Ehime University,Ehime,Japan,3DepartmentofBasicMedicalResearchandEducation,EhimeUniversityGraduateSchoolofMedicine,Ehime,Japan,4LaboratoryofMolecular Biology,FacultyofPharmacy,OsakaOhtaniUniversity, Osaka,Japan, 5DoctoralPrograminLifeSystemMedicalSciences,Graduate SchoolofComprehensiveHuman Sciences,UniversityofTsukuba,Ibaraki,Japan,6DepartmentofHealthandNutritionalScience,FacultyofHumanHealthScience,MatsumotoUniversity,Nagano,Japan, 7Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan, 8Department of Geriatric Medicine, Ehime University Graduate SchoolofMedicine,Ehime,Japan Abstract Insulinresistanceisafeatureoftype2diabetes.Resistin,secretedfromadipocytes,causesinsulinresistanceinmice.We previously reported that theG/G genotype of single nucleotidepolymorphism (SNP) at 2420(rs1862513) in the human resistin gene (RETN) increased susceptibility to type 2 diabetes by enhancing its promoter activity. Plasma resistin was highest in Japanese subjects with G/G genotype, followed by C/G, and C/C. In this study, we cross-sectionally analyzed plasmaresistinandSNPsintheRETNregionin2,019community-dwellingJapanesesubjects.Plasmaresistinwasassociated with SNP-638 (r, SNP-537 (r, SNP-420, SNP-358 (rs3219175), SNP+299 (rs3745367), and SNP+1263 213 + inallcases).SNP-638,SNP-420,SNP-358,andSNP 157wereinthesamelinkagedisequilibrium(LD) (rs3745369)(P,10 block.SNP-358andSNP-638werenearlyincompleteLD(r2=0.98),andweretightlycorre