ACE ID Gene Polymorphism Cant Predict the Steroid Responsiveness in Asian Children with Idiopathic Nephrotic Syndrome A Meta-Analysis 英文参考文献.docVIP

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ACE ID Gene Polymorphism Cant Predict the Steroid Responsiveness in Asian Children with Idiopathic Nephrotic Syndrome A Meta-Analysis 英文参考文献.doc

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ACE ID Gene Polymorphism Cant Predict the Steroid Responsiveness in Asian Children with Idiopathic Nephrotic Syndrome A Meta-Analysis 英文参考文献

ACEI/DGenePolymorphismCan’tPredicttheSteroid ResponsivenessinAsianChildrenwithIdiopathic NephroticSyndrome:AMeta-Analysis Tian-BiaoZhou.,Yuan-HanQin*.,Li-NaSu,Feng-YingLei,Wei-FangHuang,Yan-JunZhao DepartmentofPediatrics,TheFirstAffiliatedHospitalofGuangXiMedicalUniversity,NanNing,China Abstract Background: The results from the published studies on the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and the treatment response to steroid in Asian children with idiopathic nephrotic syndrome (INS) is still conflicting. This meta-analysis was performed to evaluate the relation between ACE I/D gene polymorphism and treatment response to steroid in Asian children and to explore whether ACE D allele or DD genotypecouldbecomeapredictivemarkerforsteroidresponsiveness. Methodology/Principal Findings: Association studies were identified from the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of September 1, 2010, and eligible investigations were synthesizedusingmeta-analysismethod.FiveinvestigationswereidentifiedfortheanalysisofassociationbetweenACEI/D genepolymorphismandsteroid-resistantnephroticsyndrome(SRNS)riskinAsianchildrenandsevenstudieswereincluded to explore the relationship between ACE I/D gene polymorphism and steroid-sensitive nephrotic syndrome (SSNS) susceptibility.FiveinvestigationswererecruitedtoexplorethedifferenceofACEI/DgenedistributionbetweenSRNSand SSNS.TherewasnoamarkedlyassociationbetweenDalleleorDDgenotypeandSRNSsusceptibilityorSSNSrisk,andthe gene distribution differences of ACE between SRNS and SSNS were not statistically significant. II genotype might play a positiveroleagainstSRNSonsetbutnotforSSNS(OR=0.51,P=0.02;OR=0.95,P=0.85;respectively),however,theresult fortheassociationofIIgenotypewithSRNSriskwasnotstable. Conclusions/Significance: Our results indicate that D allele or DD homozygous can’t become a significant genetic molecularmarkertopredi