Adenoviral Delivery of the EMX2 Gene Suppresses Growth in Human Gastric Cancer 英文参考文献.docVIP

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Adenoviral Delivery of the EMX2 Gene Suppresses Growth in Human Gastric Cancer 英文参考文献.doc

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Adenoviral Delivery of the EMX2 Gene Suppresses Growth in Human Gastric Cancer 英文参考文献

AdenoviralDeliveryoftheEMX2GeneSuppresses GrowthinHumanGastricCancer JieLi1,MinliMo1,ZhaoChen1,ZheChen1,QingSheng2,HangMu1,3,FangZhang3,YiZhang4,Xiu-YiZhi4, HuiLi5,BiaoHe5*,Hai-MengZhou1,3* 1ProteinScienceLaboratoryofMinistryofEducation,SchoolofLifeSciences,TsinghuaUniversity,Beijing,China,2CollegeofLifeSciences,ZhejiangSci-TechUniversity, Hangzhou,China,3ZhejiangProvincialKeyLaboratoryofAppliedEnzymology,YangtzeDeltaRegionInstituteofTsinghuaUniversity,Jiaxing,Zhejiang,China,4Xuanwu Hospital,CapitalMedicalUniversity,Beijing,China,5DepartmentofSurgery,HelenDillerFamilyComprehensiveCancerCenter,UniversityofCaliforniaSanFrancisco,San Francisco,California,UnitedStatesofAmerica Abstract Background:EMX2isahumanorthologueoftheDrosophilaemptyspiracleshomeoboxgenethathasbeenimplicatedin embryogenesis. Recent studies suggest possible involvement of EMX2 in human cancers; however, the role of EMX2 in carcinogenesisneedsfurtherexploration. Results: In this study, we reported that down-regulation of EMX2 expression was significantly correlated with EMX2 promoter hypermethylation in gastric cancer. Restoring EMX2 expression using an adenovirus delivery system in gastric cancercelllineslackingendogenousEMX2expressionledtoinhibitionofcellproliferationandWntsignalingpathwayboth invitroandinagastriccancerxenograftmodelinvivo.Inaddition,weobservedthatanimalstreatedwiththeadenoviral EMX2expressionvectorhadsignificantlybettersurvivalthanthosetreatedwithemptyadenoviralvector. Conclusion:OurstudysuggeststhatEMX2isaputativetumorsuppressorinhumangastriccancer.Theadenoviral-EMX2 mayhavepotentialasanovelgenetherapyforthetreatmentofpatientswithgastriccancer. Citation:LiJ,MoM,ChenZ,ChenZ,ShengQ,etal.(2012)AdenoviralDeliveryoftheEMX2GeneSuppressesGrowthinHumanGastricCancer.PLoSONE7(9): e45970.doi:10.1371/journal.pone.0045970 Editor:MasaruKatoh,NationalCancerCenter,Japan ReceivedApril13,2012;AcceptedAugust23,2012;PublishedSeptember21,2012 Copyright:?2012Lietal.Thisisanopen-accessarticledistribu