Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context 英文参考文献.docVIP

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2017-05-11 发布于上海
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Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context 英文参考文献.doc

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Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context 英文参考文献

AgingandEnvironmentalExposuresAlterTissue-Specific DNAMethylationDependentuponCpGIslandContext BrockC.Christensen1,2,E.AndresHouseman2,3,CarmenJ.Marsit1,ShichunZheng4,MargaretR. Wrensch4,JosephL.Wiemels5,HeatherH.Nelson6,MargaretR.Karagas7,JamesF.Padbury8 ,Raphael Bueno9,DavidJ.Sugarbaker9,Ru-FangYeh5,JohnK.Wiencke4,KarlT.Kelsey1,2* 1DepartmentofPathologyandLaboratoryMedicine,BrownUniversity,Providence,RhodeIsland,UnitedStatesofAmerica,2DepartmentofCommunityHealth,Center forEnvironmentalHealthandTechnology,BrownUniversity,Providence,RhodeIsland,UnitedStatesofAmerica,3DepartmentofBiostatistics,HarvardSchoolofPublic Health,Boston,Massachusetts,UnitedStatesofAmerica,4DepartmentofNeurologicalSurgery,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,United StatesofAmerica,5DepartmentofEpidemiologyandBiostatistics,UniversityofCaliforniaSanFrancisco,SanFrancisco,California,UnitedStatesofAmerica,6Masonic CancerCenter,DivisionofEpidemiologyandCommunityHealth,UniversityofMinnesota,Minneapolis,Minnesota,UnitedStatesofAmerica,7SectionofBiostatisticsand Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 8Department of Pediatrics,WomenandInfantsHospitalandBrownUniversity,Providence,RhodeIsland,UnitedStatesofAmerica,9DivisionofThoracicSurgery,BrighamandWomen’s Hospital,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica Abstract Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human diseases, interindividualepigeneticvariationsinnormaltissuesduetoaging,environmentalfactors,orinnatesusceptibilityarepoorly characterized.Theplasticity,tissue-specificnature,andvariabilityofgeneexpressionarerelatedtoepigenomicstatesthat varyacrossindividuals.Thus,population-basedinvestigationsareneededtofurtherourunderstandingofthefun