AGT M235T GenotypeAnxiety Interaction and Gender in the HyperGEN Study 英文参考文献.docVIP

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AGT M235T GenotypeAnxiety Interaction and Gender in the HyperGEN Study 英文参考文献.doc

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AGT M235T GenotypeAnxiety Interaction and Gender in the HyperGEN Study 英文参考文献

AGTM235TGenotype/AnxietyInteractionandGenderin theHyperGENStudy SarahS.Knox1*,XinxinGuo2,YuqingZhang3,G.Weidner4,ScottWilliams5,R.CurtisEllison3 1Department of Community Medicine, Mary Babb Randolf Cancer Center, West Virginia University School of Medicine, Morgontown, West Virginia, United States of America,2OutcomeSciencesInc.,Cambridge,Massachusetts,UnitedStatesofAmerica,3PreventiveMedicineandEpidemiology,EvansDepartmentofMedicine,Boston UniversitySchoolofMedicine,Boston,Massachusetts,UnitedStatesofAmerica,4DepartmentofBiology,SanFranciscoStateUniversity,Tiburon,California,UnitedStates ofAmerica,5CenterforHumanGeneticsResearch,VanderbiltUniversity,Nashville,Tennessee,UnitedStatesofAmerica Abstract Background: Both anxiety and elevated heart rate (HR) have been implicated in the development of hypertension. The HyperGen cohort, consisting of siblings with severe and mild hypertension, an age-matched random sample of persons from the same base populations, and unmedicated adult offspring of the hypertensive siblings (N=1,002 men and 987 women), was analyzed for an association of the angiotenisinogen AGTM235T genotype (TT, MT, MM) with an endophenotype,heartrate(HR)inhighandlowanxiousgroups. Methodology: The interaction of AGTM genotype with anxiety, which has been independently associated with hypertension, was investigated adjusting for age, hypertension status, smoking, alcohol consumption, beta blocker medication,bodymassindex,physicalactivityandhoursoftelevisionviewing(sedentarylifestyle). PrincipalFindings:AlthoughtherewasnomaineffectofgenotypeonHRinmenorwomen,highanxiousmenwiththeTT genotype had high HR, whereas high anxious men with the MM genotype had low HR. In women, HR was inversely associatedwithanxietybuttherewasnointeractionwithgenotype. Conclusion/Significance: The results suggest that high anxiety in men with the TT genotype may increase risk for hypertension whereas the MM genotype may be protective in high anxious men. This type of gene x env