Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-κB Signaling Pathways 英文参考文献.docVIP

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Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-κB Signaling Pathways 英文参考文献.doc

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Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-κB Signaling Pathways 英文参考文献

AmeliorationofExperimentalAutoimmune EncephalomyelitisbyPlumbaginthroughDown- RegulationofJAK-STATandNF-kBSignalingPathways YanJia1.,JiJing1.,YangBai1,ZhenLi1,LandeLiu1,JianLuo1,MingyaoLiu1,2,HuaqingChen1* 1InstituteofBiomedicalSciencesandSchoolofLifeSciences,EastChinaNormalUniversity,Shanghai,China,2DepartmentofMolecularandCellularMedicine,Instituteof BiosciencesandTechnology,TexasAMUniversityHealthScienceCenter,Houston,Texas,UnitedStatesofAmerica Abstract Plumbagin(PL),aherbalcompoundderivedfromrootsofthemedicinalplantPlumbagozeylanica,hasbeenshowntohave immunosuppressiveproperties.PresentreportdescribesthatPLisapotentnovelagentincontrolofencephalitogenicTcell responsesandameliorationofmouseexperimentalautoimmuneencephalomyelitis(EAE),throughdown-regulationofJAK- + STATpathway.PLwasfoundtoselectivelyinhibitIFN-candIL-17productionbyCD4 Tcells,whichwasmediatedthrough abrogatedphosphorylationofJAK1andJAK2.ConsistentwithIFN-candIL-17reductionwassuppressedSTAT1/STAT4/T- bet pathway which is critical for Th1 differentiation, as well as STAT3/ROR pathway which is essential for Th17 differentiation. In addition, PL suppressed pro-inflammatory molecules such as iNOS, IFN-c and IL-6, accompanied by inhibition of IkB degradation as well as NF-kB phosphorylation. These data give new insight into the novel immune regulatorymechanismofPLandhighlightthegreatvalueofthiskindofherbcompoundsinprobingthecomplexcytokine signalingnetworkandnoveltherapeutictargetsforautoimmunediseases. Citation:JiaY,JingJ,BaiY,LiZ,LiuL,etal.(2011)AmeliorationofExperimentalAutoimmuneEncephalomyelitisbyPlumbaginthroughDown-RegulationofJAK- STATandNF-kBSignalingPathways.PLoSONE6(10):e27006.doi:10.1371/journal.pone.0027006 Editor:Malu′ G.Tansey,EmoryUniversity,UnitedStatesofAmerica ReceivedJune1,2011;AcceptedOctober7,2011;PublishedOctober31,2011 Copyright:?2011Jiaetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,an