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An Analytically Solvable Model for Rapid Evolution of Modular Structure 英文参考文献
AnAnalyticallySolvableModelforRapidEvolutionof
ModularStructure
NadavKashtan1.,AviE.Mayo1.,TomerKalisky1,UriAlon1,2*
1DepartmentofMolecularCellBiology,WeizmannInstituteofScience,Rehovot,Israel,2PhysicsofComplexSystems,WeizmannInstituteofScience,Rehovot,Israel
Abstract
Biologicalsystemsoftendisplaymodularity,inthesensethattheycanbedecomposedintonearlyindependentsubsystems.
Recentstudieshavesuggestedthatmodularstructurecanspontaneouslyemergeifgoals(environments)changeovertime,
suchthateachnewgoalsharesthesamesetofsub-problemswithpreviousgoals.Suchmodularlyvaryinggoalscanalso
dramaticallyspeedupevolution,relativetoevolutionunderaconstantgoal.Thesestudieswerebasedonsimulationsof
modelsystems,suchaslogiccircuitsandRNAstructure,whicharegenerallynoteasytotreatanalytically.Wepresent,here,
asimplemodelforevolutionundermodularlyvaryinggoalsthatcanbesolvedanalytically.Thismodelhelpstounderstand
someofthefundamentalmechanismsthatleadtorapidemergenceofmodularstructureundermodularlyvaryinggoals.In
particular,themodelsuggestsamechanismforthedramaticspeedupinevolutionobservedundersuchtemporallyvarying
goals.
Citation:KashtanN,MayoAE,KaliskyT,AlonU(2009)AnAnalyticallySolvableModelforRapidEvolutionofModularStructure.PLoSComputBiol5(4):e1000355.
doi:10.1371/journal.pcbi.1000355
Editor:CarlT.Bergstrom,UniversityofWashington,UnitedStatesofAmerica
ReceivedJune23,2008;AcceptedMarch10,2009;PublishedApril10,2009
Copyright: ? 2009 Kashtan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:NIH,KahnFamilyfoundation,CenterofComplexityScience.Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,
orpreparationofthemanuscript.
CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist.
*E-mail:urialon@weizmann.ac.il
.Theseauthorscontributedequallytothiswork
Introduction
modular
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