An Ethanol Extract of Artemisia iwayomogi Activates PPARδ Leading to Activation of Fatty Acid Oxidation in Skeletal Muscle 英文参考文献.docVIP

下载本文档

4
0
约3.42万字
约 8页
2017-05-11 发布于上海
举报
版权申诉

An Ethanol Extract of Artemisia iwayomogi Activates PPARδ Leading to Activation of Fatty Acid Oxidation in Skeletal Muscle 英文参考文献.doc

1、本文档共8页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

An Ethanol Extract of Artemisia iwayomogi Activates PPARδ Leading to Activation of Fatty Acid Oxidation in Skeletal Muscle 英文参考文献

AnEthanolExtractofArtemisiaiwayomogiActivates PPARdLeadingtoActivationofFattyAcidOxidationin SkeletalMuscle SiYoungCho,HyunWooJeong,JongHeeSohn,Dae-BangSeo,WanGiKim,Sang-JunLee* HealthScienceResearchInstitute,ResearchandDevelopmentCenter,AmorePacificCorporation,Bora-dong,Giheung-gu,Yongin-si,Korea Abstract Although Artemisia iwayomogi (AI) has been shown to improve the lipid metabolism, its mode of action is poorly understood.Inthisstudy,a95%ethanolextractofAI(95EEAI)wasidentifiedasapotentligandofperoxisomeproliferator- activatedreceptord(PPARd)usingligandbindinganalysisandcell-basedreporterassay.Inculturedprimaryhumanskeletal muscle cells, treatment of 95EEAI increased expression of two important PPARd-regulated genes, carnitine palmitoyl- transferase-1 (CPT1) and pyruvate dehydrogenase kinase isozyme 4 (PDK4), and several genes acting in lipid efflux and energy expenditure. Furthermore, 95EEAI stimulated fatty acid oxidation in a PPARd-dependent manner. High-fat diet- induced obese mice model further indicated that administration of 95EEAI attenuated diet-induced obesity through the activationoffattyacidoxidationinskeletalmuscle.Theseresultssuggestthata95%ethanolextractofAImayhavearoleas anewfunctionalfoodmaterialforthepreventionand/ortreatmentofhyperlipidermiaandobesity. Citation:ChoSY,JeongHW,SohnJH,SeoD-B,KimWG,etal.(2012)AnEthanolExtractofArtemisiaiwayomogiActivatesPPARdLeadingtoActivationofFatty AcidOxidationinSkeletalMuscle.PLoSONE7(3):e33815.doi:10.1371/journal.pone.0033815 Editor:KrisztianStadler,PenningtonBiomedicalResearchCenter,UnitedStatesofAmerica ReceivedNovember9,2011;AcceptedFebruary17,2012;PublishedMarch27,2012 Copyright:?2012Choetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Nocurrentexternalfundingsourcesforthisstudy. Competing Interests: The authors have read the journal’s po