Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohns Disease 英文参考文献.docVIP

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Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohns Disease 英文参考文献.doc

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Association of Variants at 1q32 and STAT3 with Ankylosing Spondylitis Suggests Genetic Overlap with Crohns Disease 英文参考文献

AssociationofVariantsat1q32andSTAT3with AnkylosingSpondylitisSuggestsGeneticOverlapwith Crohn’sDisease PatrickDanoy1,KarenaPryce1,JohannaHadler1,LindaA.Bradbury1,ClaireFarrar2,JenniferPointon2, Australo-Anglo-AmericanSpondyloarthritisConsortium(TASC),MichaelWard3,MichaelWeisman4, JohnD.Reveille5,B.PaulWordsworth2,MillicentA.Stone6,SpondyloarthritisResearchConsortiumof Canada(SPARCC),WalterP.Maksymowych7,ProtonRahman8,DafnaGladman9,RobertD.Inman9, MatthewA.Brown1,2 * 1The University of Queensland Diamantina Institute, Brisbane, Australia, 2University of Oxford Institute of Musculoskeletal Sciences and NIHR Biomedical Research Centre, Nuffield Orthopaedic Centre, Oxford, United Kingdom, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda,Maryland,UnitedStatesofAmerica,4DepartmentofMedicine/Rheumatology,Cedars-SinaiMedicalCentre,LosAngeles,California,UnitedStatesofAmerica, 5RheumatologyandClinicalImmunogenetics,UniversityofTexasHealthScienceCenteratHouston,Houston,Texas,UnitedStatesofAmerica,6UniversityofBath,Bath, United Kingdom, 7The University of Alberta, Edmonton, Alberta, Canada, 8Memorial University, St. Johns, Newfoundland, Canada, 9University of Toronto, Toronto, Ontario,Canada Abstract Ankylosingspondylitis(AS)isacommoninflammatoryarthriticcondition.Overtinflammatoryboweldisease(IBD)occursin about 10% of AS patients, and in addition 70% of AS cases may have subclinical terminal ileitis. Spondyloarthritis is also commoninIBDpatients.WethereforetestedCrohn’sdiseasesusceptibilitygenesforassociationwithAS,aimingtoidentify pleiotropicgeneticassociationswithbothdiseases.GenotypingwascarriedoutusingSequenomandAppliedBiosystems TaqManandOpenArraytechnologieson53markersselectedfrom30Crohn’sdiseaseassociatedgenomicregions.Wetested genotypesinapopulationofunrelatedindividualcases(n=2,773)andcontrols(n=2,215)ofwhiteEuropeanancestryfor associationwithAS.StatisticalanalysiswascarriedoutusingaCochran-Armitagetestf