attract A Method for Identifying Core Pathways That Define Cellular Phenotypes 英文参考文献.docVIP

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attract A Method for Identifying Core Pathways That Define Cellular Phenotypes 英文参考文献.doc

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attract A Method for Identifying Core Pathways That Define Cellular Phenotypes 英文参考文献

attract:AMethodforIdentifyingCorePathwaysThat DefineCellularPhenotypes JessicaC.Mar1,2*.,NicholasA.Matigian3,JohnQuackenbush1,2,3,4*.,ChristineA.Wells 3,5 . * 1DepartmentofBiostatistics,HarvardSchoolofPublicHealth,Boston,Massachusetts,UnitedStatesofAmerica,2DepartmentofBiostatisticsandComputationalBiology, Dana-Farber CancerInstitute, Boston, Massachusetts,United States ofAmerica,3NationalCentre forAdultStemCellResearch, Eskitis Institute for CellandMolecular Therapies, Griffith University, Brisbane, Queensland, Australia, 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America,5AustralianInstituteofBioengineeringandNanotechnology,UniversityofQueensland,Brisbane,Queensland,Australia Abstract attract is a knowledge-driven analytical approach for identifying and annotating the gene-sets that best discriminate between cell phenotypes. attract finds distinguishing patterns within pathways, decomposes pathways into meta-genes representative of these patterns, and then generates synexpression groups of highly correlated genes from the entire transcriptomedataset.attractcanbeappliedtoawiderangeofbiologicalsystemsandisfreelyavailableasaBioconductor packageandhasbeenincorporatedintotheMeVsoftwaresystem. Citation:MarJC,MatigianNA,QuackenbushJ,WellsCA(2011)attract:AMethodforIdentifyingCorePathwaysThatDefineCellularPhenotypes.PLoSONE6(10): e25445.doi:10.1371/journal.pone.0025445 Editor:PeterCsermely,SemmelweisUniversity,Hungary ReceivedJune16,2011;AcceptedSeptember5,2011;PublishedOctober14,2011 Thisisanopen-accessarticle,freeofallcopyright,andmaybefreelyreproduced,distributed,transmitted,modified,builtupon,orotherwiseusedbyanyonefor anylawfulpurpose.TheworkismadeavailableundertheCreativeCommonsCC0publicdomaindedication. Funding:JQandJCMaresupportedbyagrantfromtheUSNationalHumanGenomeResearchInstitute(P50-HG004233).JQisalsosupported,inpart,bya JacksonMemorialVisitingFellowshipfromGriffithUniversity(.au)andaHarvardClubofA