Boosting of Synaptic Potentials and Spine Ca Transients by the Peptide Toxin SNX-482 Requires Alpha-1E-Encoded Voltage-Gated Ca Channels 英文参考文献.docVIP

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Boosting of Synaptic Potentials and Spine Ca Transients by the Peptide Toxin SNX-482 Requires Alpha-1E-Encoded Voltage-Gated Ca Channels 英文参考文献.doc

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Boosting of Synaptic Potentials and Spine Ca Transients by the Peptide Toxin SNX-482 Requires Alpha-1E-Encoded Voltage-Gated Ca Channels 英文参考文献

BoostingofSynapticPotentialsandSpineCaTransients bythePeptideToxinSNX-482RequiresAlpha-1E- EncodedVoltage-GatedCaChannels AndrewJ.Giessel,BernardoL.Sabatini* DepartmentofNeurobiology,HowardHughesMedicalInstitute,HarvardMedicalSchool,Boston,Massachusetts,UnitedStatesofAmerica Abstract The majority of glutamatergic synapses formed onto principal neurons of the mammalian central nervous system are associatedwithdendriticspines.Spinesaretinyprotuberancesthathousetheproteinsthatmediatetheresponseofthe postsynapticcelltothepresynapticreleaseofglutamate.Postsynapticsignalsareregulatedbyanionchannelsignaling cascadethatisactiveinindividualdendriticspinesandinvolvesvoltage-gatedcalcium(Ca)channels,smallconductance (SK)-typeCa-activatedpotassiumchannels,andNMDA-typeglutamatereceptors.Pharmacologicalstudiesusingthetoxin SNX-482indicatedthatthevoltage-gatedCachannelsthatsignalwithinspinestoopenSKchannelsbelongtotheclass CaV2.3,whichisencodedbytheAlpha-1Epore-formingsubunit.Inordertospecificallytestthisconclusion,weexamined theeffectsofSNX-482onsynapticsignalsinacutehippocampalslicesfromknock-outmicelackingtheAlpha-1Egene.We find that in these mice, application of SNX-482 has no effect on glutamate-uncaging evoked synaptic potentials and Ca influx,indicatingthatthatSNX-482indeedactsviatheAlpha-1E-encodedCaV2.3channel. Citation: Giessel AJ, Sabatini BL (2011) Boosting of Synaptic Potentials and Spine Ca Transients by the Peptide Toxin SNX-482 Requires Alpha-1E-Encoded Voltage-GatedCaChannels.PLoSONE6(6):e20939.doi:10.1371/journal.pone.0020939 Editor:OlivierJacquesManzoni,InstitutNationaldelaSante′ etdelaRechercheMe′dicale,France ReceivedMarch9,2011;AcceptedMay13,2011;PublishedJune9,2011 Copyright: ?2011Giessel, Sabatini. This isanopen-access article distributedunder theterms ofthe Creative Commons AttributionLicense, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thisworkwassupportedbygrantsfromt