Bone Turnover and Metabolism in Patients with Early Multiple Sclerosis and Prevalent Bone Mass Deficit A Population-Based Case-Control Study 英文参考文献.docVIP

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Bone Turnover and Metabolism in Patients with Early Multiple Sclerosis and Prevalent Bone Mass Deficit A Population-Based Case-Control Study 英文参考文献.doc

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Bone Turnover and Metabolism in Patients with Early Multiple Sclerosis and Prevalent Bone Mass Deficit A Population-Based Case-Control Study 英文参考文献

BoneTurnoverandMetabolisminPatientswithEarly MultipleSclerosisandPrevalentBoneMassDeficit:A Population-BasedCase-ControlStudy StineMaritMoen1*,ElisabethGulowsenCelius1,LeivSandvik2,MagrittBrustad3,LarsNordsletten4 ,Erik FinkEriksen5,TrygveHolm?y6,7 1DepartmentofNeurology,OsloUniversityHospitalUlleva?l, Oslo,Norway,2SectionofEpidemiologyandBiostatistics, OsloUniversityHospitalUlleva?l, Oslo,Norway, 3DepartmentofCommunityMedicine,UniversityofTroms?,Troms?,Norway,4OrthopedicDepartment,OsloUniversityHospitalUlleva?l,Oslo,Norway,5Departmentof Endocrinology, Oslo University Hospital, Oslo, Norway, 6Department of Neurology, Akershus University Hospital, L?renskog, Norway, 7Institute of Clinical Medicine, UniversityofOslo,Oslo,Norway Abstract Background:Lowbonemassisprevalentinambulatorymultiplesclerosis(MS)patientsevenshortlyafterclinicalonset.The mechanism is not known, but could involve shared etiological risk factors between MS and low bone mass such as hypovitaminosisDoperatingbeforediseaseonset,orincreasedbonelossafterdiseaseonset.Theaimofthisstudywasto explorethemechanismofthelowbonemassinearly-stageMSpatients. Methodology/PrincipalFindings:Weperformedapopulation-basedcase-controlstudycomparingboneturnover(cross- linkedN-terminaltelopeptideoftype1collagen;NTX,bonealkalinephosphatase;bALP),metabolism(25-hydroxy-and1, 25-dihydroxyvitaminD,calcium,phosphate,andparathyroidhormone),andrelevantlifestylefactorsin99patientsnewly diagnosed with clinically isolated syndrome (CIS) or MS, and in 159 age, sex, and ethnicity matched controls. After adjustmentforpossibleconfounders,therewerenosignificantdifferencesinNTX(mean3.3;95%CI26.9,13.5;p=0.519), bALP(mean1.6;95%CI20.2,3.5;p=0.081),orinanyoftheparametersrelatedtobonemetabolisminpatientscompared to controls. The markers of bone turnover and metabolism were not significantly correlated with bone mass density, or associatedwiththepresenceofosteoporosisorosteopeniawithinorbetweenthepatientandcontrolgroups.Intakeof vitam