Bone Tissue Response to Porous and Functionalized Titanium and Silica Based Coatings 英文参考文献.docVIP

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Bone Tissue Response to Porous and Functionalized Titanium and Silica Based Coatings 英文参考文献.doc

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Bone Tissue Response to Porous and Functionalized Titanium and Silica Based Coatings 英文参考文献

BoneTissueResponsetoPorousandFunctionalized TitaniumandSilicaBasedCoatings AmolChaudhari1,AnnabelBraem2,JozefVleugels2,JohanA.Martens3,IgnaceNaert1,MarcioVivan Cardoso1,JokeDuyck1* 1DepartmentofProstheticDentistry,BIOMATResearchGroup,K.U.Leuven,Leuven,Belgium,2DepartmentofMetallurgyandMaterialsEngineering(MTM),K.U.Leuven, Heverlee,Belgium,3CentreofSurfaceChemistryandCatalysis,K.U.Leuven,Heverlee,Belgium Abstract Background:Topographyandpresenceofbio-mimeticcoatingsareknowntoimproveosseointegration.Theobjectiveof thisstudywastoevaluatetheboneregenerationpotentialofporousandosteogeniccoatings. Methodology: Six-implants [Control (CTR); porous titanium coatings (T1, T2); thickened titanium (Ti) dioxide layer (TiO2); Amorphous Microporous Silica (AMS) and Bio-active Glass (BAG)] were implanted randomly in tibiae of 20-New Zealand white rabbits. The animals were sacrificed after 2 or 4 weeks. The samples were analyzed histologically and histomorphometrically. In the initial bone-free areas (bone regeneration areas (BRAs)), the bone area fraction (BAF) was evaluatedinthewholecavity(500mm,BAF-500),intheimplantvicinity(100mm,BAF-100)andfurtheraway(100–500mm, BAF-400)fromtheimplant.Bone-to-implantcontact(BIC-BAA)wasmeasuredintheareaswheretheimplantswereinstalled incontacttothehostbone(boneadaptationareas(BAAs))tounderstandandcomparetheboneadaptation.Mixedmodels wereusedforstatisticalanalysis. PrincipalFindings:After2weeks,thedifferencesinBAF-500fordifferentsurfaceswerenotsignificant(p.0.05).After4 weeks,ahigherBAF-500wasobservedforBAGthanCTR.BAF-100forAMSwashigherthanBAGandBAF-400forBAGwas higherthanCTRandAMS.ForT1andAMS,theboneregenerationwasfasterinthe100-mmcomparedtothe400-mmzone. BIC-BAAforAMSandBAGwaslowerafter4than2weeks.After4weeks,BIC-BAAforBAGwaslowerthanAMSandCTR. Conclusions:BAGishighlyosteogenicatadistancefromtheimplant.Theporoustitaniumcoatingsdidn’tstimulatebone regeneration but allowed bone growth into the pores. Although AMS didn’t stimulate higher bone re