Bovine Herpesvirus Type 1 (BHV-1) UL49.5 Luminal Domain Residues 30 to 32 Are Critical for MHC-I Down-Regulation in Virus-Infected Cells 英文参考文献.docVIP

下载本文档

7
0
约5.1万字
约 11页
2017-05-11 发布于上海
举报
版权申诉

Bovine Herpesvirus Type 1 (BHV-1) UL49.5 Luminal Domain Residues 30 to 32 Are Critical for MHC-I Down-Regulation in Virus-Infected Cells 英文参考文献.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Bovine Herpesvirus Type 1 (BHV-1) UL49.5 Luminal Domain Residues 30 to 32 Are Critical for MHC-I Down-Regulation in Virus-Infected Cells 英文参考文献

BovineHerpesvirusType1(BHV-1)UL49.5Luminal DomainResidues30to32AreCriticalforMHC-I Down-RegulationinVirus-InfectedCells HuiyongWei,YingWang,ShafiqulI.Chowdhury* DepartmentofPathobiologicalSciences,SchoolofVeterinaryMedicine,LouisianaStateUniversity,BatonRouge,Louisiana,UnitedStatesofAmerica Abstract Bovineherpesvirustype1(BHV-1)UL49.5inhibitstransporterassociatedwithantigenprocessing(TAP)anddown-regulates cell-surfaceexpressionofmajorhistocompatibilitycomplex(MHC)classImoleculestopromoteimmuneevasion.Wehave constructedaBHV-1UL49.5cytoplasmictail(CT)nullandseveralUL49.5luminaldomainmutantsinthebackboneofwild- typeBHV-1orBHV-1UL49.5CT-nullvirusesanddeterminedtheirrelativeTAPmediatedpeptidetransportinhibitionand MHC-1down-regulationpropertiescomparedwithBHV-1wt.Basedonourresults,theUL49.5luminaldomainresidues30– 32andUL49.5CTresidues,together,promoteefficientTAPinhibitionandMHC-Idown-regulationfunctions.Invitro,BHV-1 UL49.5D30–32CT-nullvirusgrowthpropertywassimilartothatofBHV-1wtandlikethewtUL49.5,themutantUL49.5was incorporatedinthevirionenvelopeanditformedacomplexwithgMintheinfectedcells. Citation: Wei H, Wang Y, Chowdhury SI (2011) Bovine Herpesvirus Type 1 (BHV-1) UL49.5 Luminal Domain Residues 30 to 32 Are Critical for MHC-I ?Down-RegulationinVirus-InfectedCells.PLoSONE6(10):e25742.doi:10.1371/journal.pone.0025742 Editor:HermanFavoreel,GhentUniversity,Belgium ReceivedJuly4,2011;AcceptedSeptember9,2011;PublishedOctober26,2011 Copyright:?2011Weietal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyUnitedStatesDepartmentofAgriculture(USDA)grant2007-35204-17358toSIC.Thefundershadnoroleinstudydesign, datacollectionandanalysis,decisiontopublish,orpreparationofthemanuscript. CompetingInterests:Theauthorshavedeclaredthatnocompetinginterestsexist. *E-mail:chowdh@ Introduction Alphaherpesv