Brain Processing of Biologically Relevant Odors in the Awake Rat, as Revealed by Manganese-Enhanced MRI 英文参考文献.docVIP

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Brain Processing of Biologically Relevant Odors in the Awake Rat, as Revealed by Manganese-Enhanced MRI 英文参考文献.doc

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Brain Processing of Biologically Relevant Odors in the Awake Rat, as Revealed by Manganese-Enhanced MRI 英文参考文献

BrainProcessingofBiologicallyRelevantOdorsinthe AwakeRat,asRevealedbyManganese-EnhancedMRI BenoistLehallier1,OlivierRampin2,AudreySaint-Albin2,NathalieJe′ro?me2,ChristianOuali2, YvesMaurin2,Jean-MarieBonny1* 1UR370QuaPA,INRA,Saint-Gene`s-Champanelle,France,2UR1197NOeMI,INRA,Jouy-en-Josas,France Abstract Background:Sofar,anoverallviewofolfactorystructuresactivatedbynaturalbiologicallyrelevantodorsintheawakeratis not available. Manganese-enhanced MRI (MEMRI) is appropriate for this purpose. While MEMRI has been used for anatomicallabelingofolfactorypathways,functionalimaginganalyseshavenotyetbeenperformedbeyondtheolfactory bulb. Here, we have used MEMRI for functional imaging of rat central olfactory structures and for comparing activation mapsobtainedwithodorsconveyingdifferentbiologicalmessages. Methodology/Principal Findings: Odors of male fox feces and of chocolate flavored cereals were used to stimulate conscious rats previously treated by intranasal instillation of manganese (Mn). MEMRI activation maps showed Mn enhancementallalongtheprimaryolfactorycortex.Mnenhancementelicitedbymalefoxfecesodorandtoalesserextent that elicited by chocolate odor, differed from that elicited by deodorized air. This result was partly confirmed by c-Fos immunohistochemistryinthepiriformcortex. Conclusion/Significance:Byprovidinganoverallimageofbrainstructuresactivatedinawakeratsbyodorousstimulation, andbyshowingthatMnenhancementisdifferentlysensitivetodifferentstimulatingodors,thepresentresultsdemonstrate theinterestofMEMRIforfunctionalstudiesofolfactionintheprimaryolfactorycortexoflaboratorysmallanimals,under conditionsclosetonaturalperception.Finally,thefactorsthatmaycausethevariabilityoftheMEMRIsignalinresponseto differentodorarediscussed. Citation:LehallierB,RampinO,Saint-AlbinA,Je′ro?meN,OualiC,etal.(2012)BrainProcessingofBiologicallyRelevantOdorsintheAwakeRat,asRevealedby Manganese-EnhancedMRI.PLoSONE7(10):e48491.doi:10.1371/journal.pone.0048491 Editor:HiroakiMatsunami,DukeU