Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood A 21-Year Longitudinal Study 英文参考文献.docVIP

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Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood A 21-Year Longitudinal Study 英文参考文献.doc

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Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood A 21-Year Longitudinal Study 英文参考文献

BrainSerotoninSynthesisinAdultMalesCharacterized byPhysicalAggressionduringChildhood:A21-Year LongitudinalStudy LindaBooij1¤,RichardE.Tremblay2,3,4,5,6,MarcoLeyton1,7,8,JeanR.Se′guin5,6,FrankVitaro5,9 ,Paul Gravel1,ElisabethPerreau-Linck1,Me′lissaL.Le′vesque1,FranceDurand1,MirkoDiksic7,8 ,Gustavo Turecki10,ChawkiBenkelfat1,7,8* 1DepartmentofPsychiatry,McGillUniversity,Montreal,Canada,2DepartmentsofPsychologyandPediatrics,UniversityofMontreal,Montreal,Canada,3SchoolofPublic Health and Population Sciences, University College, Dublin, Ireland, 4INSERM U669, Paris, France, 5Sainte-Justine Hospital Research Center, Montreal, Canada, 6DepartmentofPsychiatry,UniversityofMontreal,Montreal,Canada,7DepartmentofNeurologyandNeurosurgery,MontrealNeurologicalInstitute,McGillUniversity, Montreal,Canada,8McConnellBrainImagingCenter,MontrealNeurologicalInstitute,McGillUniversity,Montreal,Canada,9SchoolofPsycho-Education,Universityof Montreal,Montreal,Canada,10McGillGroupforSuicideStudies,DouglasHospital,McGillUniversity,Montreal,Canada Abstract Background: Adults exhibiting severe impulsive and aggressive behaviors have multiple indices of low serotonin (5-HT) neurotransmission. It remains unclear though whether low 5-HT mediates the behavior or instead reflects a pre-existing vulnerabilitytrait. Methodology/PrincipalFindings:Inthepresentstudy,positronemissiontomographywiththetraceralpha-[11C]methyl-L- tryptophan (11C-AMT) was used to compare 5-HT synthesis capacity in two groups of adult males from a 21-year longitudinalstudy(meanage6SD:27.160.7):individualswithahistoryofchildhood-limitedhighphysicalaggression(C- LHPA; N=8) and individuals with normal (low) patterns of physical aggression (LPA; N=18). The C-LHPA males had significantlylowertrappingof 11C-AMTbilaterallyintheorbitofrontalcortexandself-reportedmoreimpulsiveness.Despite this, in adulthood there were no group differences in plasma tryptophan levels, genotyping, aggression, emotional intelligence,workingmemory,compute