Brief Subthreshold Events Can Act as Hebbian Signals for Long-Term Plasticity 英文参考文献.docVIP

BriefSubthresholdEventsCanActasHebbianSignalsfor Long-TermPlasticity ElodieFino,Jean-MichelDeniau,LaurentVenance* DynamicsandPathophysiologyofNeuronalNetworks,INSERMU-667,Colle`ge deFrance,UniversityPierreetMarieCurie,Paris,France Abstract Background:Actionpotentialsarethoughttobedeterminantfortheinductionoflong-termsynapticplasticity,thecellular basisoflearningandmemory.However,neuronalactivitydoesnotleadsystematicallytoanactionpotentialbutalso,in many cases, to synaptic depolarizing subthreshold events. This is particularly exemplified in corticostriatal information processing. Indeed, the striatum integrates information from the whole cerebral cortex and, due to the membrane properties of striatal medium spiny neurons, cortical inputs do not systematically trigger an action potential but a wide rangeofsubthresholdpostsynapticdepolarizations.Accordingly,wehaveaddressedthefollowingquestion:doesabrief subthresholdeventactasaHebbiansignalandinducelong-termsynapticefficacychanges? Methodology/Principal Findings: Here, using perforated patch-clamp recordings on rat brain corticostriatal slices, we demonstrate,thatbrief(30ms)subthresholddepolarizingeventsinquasi-coincidencewithpresynapticactivitycanactas Hebbian signals and are sufficient to induce long-term synaptic plasticity at corticostriatal synapses. This ‘‘subthreshold- depolarization dependent plasticity’’ (SDDP) induces strong, significant and bidirectional long-term synaptic efficacy changes at a very high occurrence (81%) for time intervals between pre- and postsynaptic stimulations (Dt) of 2110,Dt,+110ms.Suchsubthresholddepolarizationsareabletoinducerobustlong-termdepression(cannabinoidtype- 1receptor-activationdependent)aswellaslong-termpotentiation(NMDAreceptor-activationdependent). Conclusion/Significance:Ourdatashowtheexistenceofarobust,reliableandtiming-dependentbidirectionallong-term plasticity induced by brief subthreshold events paired with presynaptic activity. The existence of a subthreshold-