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Brief Overview of Bioinformatics Activities in Singapore 英文参考文献.doc

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Brief Overview of Bioinformatics Activities in Singapore 英文参考文献

Perspective BriefOverviewofBioinformaticsActivitiesinSingapore FrankEisenhaber1,Chee-KeongKwoh2,See-KiongNg3,Wing-KingSung4,5,LimsoonWong5* 1BioInformatics Institute, Singapore, 2Nanyang Technological University, Singapore, 3Institute for Infocomm Research, Singapore, 4Genome Institute of Singapore, Singapore,5NationalUniversityofSingapore,Singapore Introduction After a tumultuous history with changing missionsanddirectors,BIIwasessentially relaunchedintheautumnof2007.Nowits mission is defined primarily as a compu- tationalbiologyresearchinstitute.Itsnew director, Frank Eisenhaber (previously at the Research Institute of Molecular Pa- thology in Vienna, Austria), guides the transition. divisions. The ‘‘Imaging Informatics’’ sec- tion develops automated tools for the quantificationofthedistributionoflabeled moleculeswithregardtosubcellularstruc- turesinimagesofcells.BII’sownmicros- copy lab is coming into operation in summer2009.Inthe‘‘GenomeSequence The frontier of biological and medical sciences is full of opportunity today. It is widelyappreciatedthatpresent-daybiomed- ical researchers are confronted by vast amounts of data from genome sequencing; microscopy;high-throughputanalyticaltech- niquesforDNA,RNA,andproteins;anda hostofothernewexperimentaltechnologies. Coupledwithadvancesincomputingpower, thisflowofinformationenablesscientiststo computationallymodelandanalyzebiolog- ical systems in novel ways. Therefore, bioinformatics is seen as an important ingredientinSingapore’sambitiontobean international center for the biomedical sciencesandtheirrelatedindustries. and Gene Expression Data Analysis’’ divisionorganizedbyVladimirKuznetsov, the research focus is on understanding transcriptional regulation and the biologi- cal role of non-coding RNA. Chandra Vermaguidesthe‘‘BiomolecularStructure and Design’’ division, the teams of which analyzeandsimulate3Dstructuralassem- blies of biomolecules and try to connect structuralfeatureswithbiologicalfunction. Finally