Diagnosis of Alzheimers Disease Based on Disease-Specific Autoantibody Profiles in Human Sera 英文参考文献.docVIP

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Diagnosis of Alzheimers Disease Based on Disease-Specific Autoantibody Profiles in Human Sera 英文参考文献.doc

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Diagnosis of Alzheimers Disease Based on Disease-Specific Autoantibody Profiles in Human Sera 英文参考文献

DiagnosisofAlzheimer’sDiseaseBasedonDisease- SpecificAutoantibodyProfilesinHumanSera EricNagele1.,MinHan2,3.,CassandraDeMarshall2,BenjaminBelinka1,RobertNagele3* 1DurinTechnologies,Inc.,NewBrunswick,NewJersey,UnitedStatesofAmerica,2GraduateSchoolofBiomedicalSciences,SchoolofOsteopathicMedicine,Universityof Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America, 3New Jersey Institute for Successful Aging, School of Osteopathic Medicine, UniversityofMedicineandDentistryofNewJersey,Stratford,NewJersey,UnitedStatesofAmerica Abstract After decades of Alzheimer’s disease (AD) research, the development of a definitive diagnostic test for this disease has remainedelusive.Thediscoveryofblood-bornebiomarkersyieldinganaccurateandrelativelynon-invasivetesthasbeena primarygoal.UsinghumanproteinmicroarraystocharacterizethedifferentialexpressionofserumautoantibodiesinAD andnon-dementedcontrol(NDC)groups,weidentifiedpotentialdiagnosticbiomarkersforAD.Thedifferentialsignificance of each biomarker was evaluated, resulting in the selection of only 10 autoantibody biomarkers that can effectively differentiateADserafromNDCserawithasensitivityof96.0%andspecificityof92.5%.ADserawerealsodistinguishable fromseraobtainedfrompatientswithParkinson’sdiseaseandbreastcancerwithaccuraciesof86%and92%,respectively. Results demonstrate that serum autoantibodies can be used effectively as highly-specific and accurate biomarkers to diagnoseADthroughoutthecourseofthedisease. Citation:NageleE,HanM,DeMarshallC,BelinkaB,NageleR(2011)DiagnosisofAlzheimer’sDiseaseBasedonDisease-SpecificAutoantibodyProfilesinHuman Sera.PLoSONE6(8):e23112.doi:10.1371/journal.pone.0023112 Editor:HarishPant,NationalInstitutesofHealth,UnitedStatesofAmerica ReceivedMay25,2011;AcceptedJuly6,2011;PublishedAugust3,2011 Copyright: ? 2011 Nagele et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andrep