Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity 英文参考文献.docVIP

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Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity 英文参考文献.doc

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Differential Deactivation during Mentalizing and Classification of Autism Based on Default Mode Network Connectivity 英文参考文献

DifferentialDeactivationduringMentalizingand ClassificationofAutismBasedonDefaultModeNetwork Connectivity DonnaL.Murdaugh1,SvetlanaV.Shinkareva2,HrishikeshR.Deshpande1,JingWang2,MarkR.Pennick1, RajeshK.Kana1* 1DepartmentofPsychology,UniversityofAlabamaatBirmingham,Birmingham,Alabama,UnitedStatesofAmerica,2DepartmentofPsychology,UniversityofSouth Carolina,Columbia,SouthCarolina,UnitedStatesofAmerica Abstract The default mode network (DMN) is a collection of brain areas found to be consistently deactivated during task performance. Previous neuroimaging studies of resting state have revealed reduced task-related deactivation of this networkinautism.WeinvestigatedtheDMNin13high-functioningadultswithautismspectrumdisorders(ASD)and14 typicallydevelopingcontrolparticipantsduringthreefMRIstudies(twolanguagetasksandaTheory-of-Mind(ToM)task). Eachstudyhadseparateblocksoffixation/restingbaseline.Thedatafromthetaskblocksandfixationblockswerecollated toexaminedeactivationandfunctionalconnectivity.DeficitsinthedeactivationoftheDMNinindividualswithASDwere specificonlytotheToMtask,withnogroupdifferencesindeactivationduringthelanguagetasksoracombinedlanguage andself-otherdiscriminationtask.DuringrestblocksfollowingtheToMtask,theASDgroupshowedlessdeactivationthan thecontrolgroupinanumberofDMNregions,includingmedialprefrontalcortex(MPFC),anteriorcingulatecortex,and posteriorcingulategyrus/precuneus.Inaddition,wefoundweakerfunctionalconnectivityoftheMPFCinindividualswith ASD compared to controls. Furthermore, we were able to reliably classify participants into ASD or typically developing control groups based on both the whole-brain and seed-based connectivity patterns with accuracy up to 96.3%. These findings indicate that deactivation and connectivity of the DMN were altered in individuals with ASD. In addition, these findings suggest that the deficits in DMN connectivity could be a neural signature that can be used for classifying an individualasbelongingtotheASDgroup. Citation:Mur