Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa 英文参考文献.docVIP

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Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa 英文参考文献.doc

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Drug-Resistant Tuberculosis among HIV-Infected Patients Starting Antiretroviral Therapy in Durban, South Africa 英文参考文献

Drug-ResistantTuberculosisamongHIV-Infected PatientsStartingAntiretroviralTherapyinDurban,South Africa JeffreyK.Hom1¤,BingxiaWang2,SenicaChetty3,JanetGiddy3,MatildaMazibuko3,JennyAllen4, RochelleP.Walensky1,2,5,6,9,11,ElenaLosina1,2,6,7,10,11,KennethA.Freedberg1,2,6,8,11 IngridV.Bassett1,2,5,6,11 , * 1Harvard Medical School, Boston, Massachusetts, United States of America, 2Division of General Medicine, Massachusetts General Hospital, Boston, Massachusetts, UnitedStatesofAmerica,3McCordHospital,Durban,SouthAfrica,4UniversityofKwaZulu-NatalMicrobiologyLaboratoryandtheMedicalResearchCouncil,Durban, South Africa, 5Division of Infectious Disease, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 6Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 7Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, UnitedStatesofAmerica, 8DepartmentofEpidemiology,BostonUniversity SchoolofPublicHealth,Boston, Massachusetts,United StatesofAmerica, 9DivisionofInfectiousDisease,BrighamandWomen’sHospital,Boston,Massachusetts,UnitedStatesofAmerica,10DepartmentofOrthopedics,BrighamandWomen’s Hospital, Boston, Massachusetts, United States of America, 11Harvard Center for AIDS Research (CFAR), Harvard University, Boston, Massachusetts, United States of America Abstract Objective:Toestimatetheprevalenceofdrug-resistanttuberculosis(TB)anddescribetheresistancepatternsinpatients commencingantiretroviraltherapy(ART)inanHIVclinicinDurban,SouthAfrica. Design:Cross-sectionalcohortstudy. Methods:ConsecutiveHIV-infectedadults($18y/o)initiatingHIVcarewereenrolledfromMay2007–May2008,regardless of signs or symptoms of active TB. Prior TB history and current TB treatment status were self-reported. Subjects expectoratedsputumforculture(MGITliquidand7H11solidmedium).Positiveculturesweretestedforsusceptibilityto first-andsecond-lineanti-tuberculousdrugs.Theprevalenceo