Downregulation of Six MicroRNAs Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix 英文参考文献.docVIP

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Downregulation of Six MicroRNAs Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix 英文参考文献.doc

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Downregulation of Six MicroRNAs Is Associated with Advanced Stage, Lymph Node Metastasis and Poor Prognosis in Small Cell Carcinoma of the Cervix 英文参考文献

DownregulationofSixMicroRNAsIsAssociatedwith AdvancedStage,LymphNodeMetastasisandPoor PrognosisinSmallCellCarcinomaoftheCervix LongHuang1,2,Jia-XinLin1,2,Yan-HongYu3,Mei-YinZhang1,Hui-YunWang1*,MinZheng1,2* 1State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China, 2Department of Gynecology, Cancer Center, Sun Yat-sen University, Guangzhou, People’s Republic of China, 3Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University,Guangzhou,People’sRepublicofChina Abstract Background: Small cell carcinoma of the cervix (SCCC) is very rare, and due to the long time period required to recruit sufficientnumbersofpatients,thereisapaucityofinformationregardingtheprognosticfactorsassociatedwithsurvival. MicroRNAs (miRNAs) have been used as cancer-related biomarkers in avariety of tumor types, and the objective of this studywastodeterminewhethermicroRNAexpressionprofilescanpredictclinicaloutcomeinSCCC. Methodology/Principal Findings: Forty-four patients with SCCC who underwent radical hysterectomy between January 2000 and October 2009 were enrolled. Using the GeneCopoeia All-in-OneTM Customized Human qPCR Primer Array, the expression profiles of 30 miRNAs associated with tumor metastasis was obtained from the formalin-fixed paraffin embeddedsamplesofall44patients.SevenmiRNAs,has-let-7c,has-miR-10b,has-miR-100,has-miR-125b,has-miR-143,has- miR-145andhas-miR-199a-5pweresignificantlydown-regulatedinadvancedstageSCCCpatients(FIGOIB2-IV)compared toearlystageSCCCpatients(FIGOIB1).Among,downregulationofsixmiRNAs,has-let-7c,has-miR-100,has-miR-125b,has- miR-143,has-miR-145andhas-miR-199a-5pweresignificantlyassociatedwithlymphnodemetastasisandreducedsurvival inSCCC.Kaplan–MeiersurvivalanalysesrevealedthatSCCCpatientswithlowexpressionofhas-miR-100(P=0.019)andhas- miR-125b(P=0.020)projectedasignificanttendencytowardspoorerprognosis. Conclusions/Significance: This study demonstrates that