Dysregulation of Th17 Cells during the Early Post-Transplant Period in Patients under Calcineurin Inhibitor Based Immunosuppression 英文参考文献.docVIP

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Dysregulation of Th17 Cells during the Early Post-Transplant Period in Patients under Calcineurin Inhibitor Based Immunosuppression 英文参考文献.doc

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Dysregulation of Th17 Cells during the Early Post-Transplant Period in Patients under Calcineurin Inhibitor Based Immunosuppression 英文参考文献

DysregulationofTh17CellsduringtheEarlyPost- TransplantPeriodinPatientsunderCalcineurinInhibitor BasedImmunosuppression ByungHaChung1,2,3.,KyoungWoonKim1.,Bo-MiKim1,ShangGuoPiao1,2,SunWooLim1,2 ,Bum SoonChoi2,3,CheolWheePark2,3,Yong-SooKim2,3,Mi-LaCho1*,ChulWooYang 1,2,3 * 1ConvergentResearchConsortiumforImmunologicDisease,SeoulSt.Mary’sHospital,CollegeofMedicine,TheCatholicUniversityofKoreaSeoul,Seoul,Republicof Korea, 2Transplant Research Center, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea Seoul, Seoul, Republic of Korea, 3Division of Nephrology,DepartmentofInternalMedicine,SeoulSt.Mary’sHospital,CollegeofMedicine,TheCatholicUniversityofKoreaSeoul,Seoul,RepublicofKorea Abstract AccumulatingevidencesuggeststhatTh17cellsplayaroleinthedevelopmentofchronicallograftinjuryintransplantation ofvariousorgans.However,theinfluenceofcurrentimmunosuppressantsonTh17-associatedimmuneresponseshasnot been fully investigated. We prospectively investigated the changes in Th17 cells in peripheral blood mononuclear cells (PBMCs) collected before and 1 and 3 months after KT in 26 patients and we investigated the suppressive effect of tacrolimusonTh17invitro.Intheearlyposttransplantperiod,thepercentageofTh17cellsandtheproportionofIL-17- producing cells in the effector memory T cells (TEM) were significantly increased at 3 months after transplantation compared with before transplantation (P,0.05), whereas Th1/Th2 cells and TEM cells were significantly decreased. The degreeofincreaseinTh17duringtheearlyposttransplantperiodwassignificantlyassociatedwithallograftfunctionat1 yearaftertransplantation(r=0.4,P,0.05).Invitro,tacrolimussuppressedTh1andTh2cellsinaconcentration-dependent manner,butdidnotsuppressTh17cellsevenathighconcentration.Thissuggeststhatcurrentimmunosuppressionbased on tacrolimus is inadequate to suppress Th17 cells in KTRs, and dysregulation of Th17 may be associated with the progressionofCAD. Citation: Chung BH, Kim KW, Kim B-M, Piao SG