Effect of Fish Oil Supplementation on Fasting Vascular Endothelial Function in Humans A Meta-Analysis of Randomized Controlled Trials 英文参考文献.docVIP

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Effect of Fish Oil Supplementation on Fasting Vascular Endothelial Function in Humans A Meta-Analysis of Randomized Controlled Trials 英文参考文献.doc

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Effect of Fish Oil Supplementation on Fasting Vascular Endothelial Function in Humans A Meta-Analysis of Randomized Controlled Trials 英文参考文献

EffectofFishOilSupplementationonFastingVascular EndothelialFunctioninHumans:AMeta-Analysisof RandomizedControlledTrials WeiXin1,WeiWei2,XiaoyingLi1* 1FirstDepartmentofGeriatricCardiology,ChinesePLAGeneralHospital,Beijing,PRChina,2MedicalCollegeofNankaiUniversity,Tianjin,PRChina Abstract Background: Effect of fish oil supplementation on flow-mediated dilation, an index of endothelial function in humans, remains controversial. We performed a meta-analysis to determine whether fish oil supplementation could improve endothelialfunction. Methods:HumaninterventionstudieswereidentifiedbysystematicsearchesofMedline,Embase,Cochrane’slibraryand references of related reviews and studies. A random-effect model was applied to estimate the pooled results. Meta- regressionandsubgroupanalyseswereperformedtoevaluatetheimpactofstudycharacteristicsontheeffectoffishoil supplementationonflow-mediateddilation. Results:Atotalofsixteenrecordswith1,385subjectswerereviewed.Theresultsofthepooledanalysisshowedthatfishoil supplementationsignificantlyimprovedflow-mediateddilation(weighedmeandifference:1.49%,95%confidenceinterval 0.48% to 2.50%, p=0.004). Meta-regression and subgroup analysis suggested that the quality of included studies were inverselyrelatedtotheoveralleffect(regressioncoefficient =21.60,p=0.04),andthesignificanceoftheeffectwasmainly drivenbythestudieswithrelativelypoorquality.Sensitivityanalysisincludingonlydouble-blind,placebo-controlledstudies indicatedfishoilsupplementationhasnosignificanteffectonendothelialfunction(weighedmeandifference:0.54%,95% confidenceinterval20.25%to1.33%,p=0.18).Besides,normoglycemicsubjectsorparticipantswithlowerdiastolicblood pressureseemedtobeassociatedwithremarkableimprovementofendothelialfunctionafterfishoilsupplementation. Conclusions:Althoughcurrentevidencesuggestedapossibleroleoffishoilinimprovingendothelialfunction,large-scale andhigh-qualityclinicaltrialsareneededtoevaluatetheseeffectsbeforewecancometoadefiniteconclusion. Citation: Xi